ID D7TJN1_VITVI Unreviewed; 524 AA.
AC D7TJN1;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Nucleobase-ascorbate transporter 2 {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=VIT_10s0003g01460 {ECO:0000313|EMBL:CBI30703.3};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CBI30703.3, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RX PubMed=17721507; DOI=10.1038/nature06148;
RG The French-Italian Public Consortium for Grapevine Genome Characterization.;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; FN595992; CBI30703.3; -; Genomic_DNA.
DR RefSeq; XP_002265912.2; XM_002265876.4.
DR AlphaFoldDB; D7TJN1; -.
DR STRING; 29760.D7TJN1; -.
DR PaxDb; 29760-VIT_10s0003g01460-t01; -.
DR EnsemblPlants; Vitvi10g00602_t001; Vitvi10g00602_P001; Vitvi10g00602.
DR GeneID; 100244635; -.
DR Gramene; Vitvi10g00602_t001; Vitvi10g00602_P001; Vitvi10g00602.
DR KEGG; vvi:100244635; -.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_3_1; -.
DR InParanoid; D7TJN1; -.
DR OMA; AHANSEM; -.
DR OrthoDB; 345287at2759; -.
DR Proteomes; UP000009183; Chromosome 10.
DR ExpressionAtlas; D7TJN1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR NCBIfam; NF037981; NCS2_1; 1.
DR PANTHER; PTHR11119:SF106; NUCLEOBASE-ASCORBATE TRANSPORTER 2; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 524 AA; 57631 MW; 4F75DCE9BC2AA70C CRC64;
MAAPKPEEIS HPPMDQIQGF EYCIDSNPSW AEAIALGFQH YILALGTAVM IPSFLVPLMG
GTDDDKVRVV QTLLFVEGIN TLLQTLFGTR LPTVVGGSYA FMVPVISIIH DSSLMEISDP
HQRFLNTMRA IQGALIVASS IQIILGYSQI WAICSRFFSP LGMVPVISLV GFGLFDRGFP
VLGRCVEIGI PMLFLFIAFS QYLKHFQTKQ LPVLERFALL ISVTVIWAYA HLLTASGAYR
HRPETTQHNC RTDKANLISS APWIKIPYPL QWGAPTFDAG HAFGMMAAVL VSLIESTGAY
KAASRLASAT PPPAHVLSRG IGWQGIGILL SGLFGTSTGS TVSVENVGLL GSTRVGSRRV
IQISAGFMIF FSILGKFGAL FASIPFTIFA AVYCVLFGLV ASVGLSFLQF TNMNSMRNLF
ITGVAFFLGL SIPEYFREYT SAALHGPAHT RAGWFNDFLN TIFFSSPTVA LIVAIFLDNT
LDYKDSARDR GMPWWVKFRT FKGDSRNEEF YTLPFNLNRF FPPS
//
