ID D7UXP6_LISGR Unreviewed; 752 AA.
AC D7UXP6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EFI84454.1};
GN Name=pbp2 {ECO:0000313|EMBL:EFI84454.1};
GN ORFNames=HMPREF0556_11007 {ECO:0000313|EMBL:EFI84454.1};
OS Listeria grayi DSM 20601.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=525367 {ECO:0000313|EMBL:EFI84454.1, ECO:0000313|Proteomes:UP000010119};
RN [1] {ECO:0000313|EMBL:EFI84454.1, ECO:0000313|Proteomes:UP000010119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20601 {ECO:0000313|EMBL:EFI84454.1,
RC ECO:0000313|Proteomes:UP000010119};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFI84454.1}.
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DR EMBL; ACCR02000003; EFI84454.1; -; Genomic_DNA.
DR RefSeq; WP_003758233.1; NZ_GL538353.1.
DR AlphaFoldDB; D7UXP6; -.
DR STRING; 525367.HMPREF0556_11007; -.
DR eggNOG; COG0768; Bacteria.
DR eggNOG; COG2815; Bacteria.
DR HOGENOM; CLU_009289_6_1_9; -.
DR Proteomes; UP000010119; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000010119};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 598..658
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 659..715
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 716..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 82509 MW; D08DF02B47EB6BB3 CRC64;
MKRRIGNRRR GALLLVALFT VLFLALAAKF LYLQISGYSN GVPLAAKAAK QHLKSTTIDA
KRGSILDSKG EVLAEDTSTF TLAAVLSKDA SKDQKTPLHV VDKEKTAEVL AKYLPIKEDA
VLKELQKKDK YQVEFGAAGK NISVATKEKI EKAKLPGLIF TRQAERFYPN GVLAAEVIGF
AQRDEKTNQL VGKMGLEKQL NDELEGKDGK LNYSTDRMGY ILPNSKTNVK PAVDGKNITL
TTDKKIQTFL EDTMNSVNEK YHPKNMMAVV ANPKTGEILA MSQRPTFNPS TKAGLESKNS
GVWQDLPVEY AYEPGSVMKV FSLASAIDAG VYNPNEYYKS GIYKVGDIQI HDHNRVGWGS
IPFREGLERS SNVAFARLLD KLGTDRFLSY LKKFKFGEKT GVDLPNESSG KIVYNYPVEK
VTNVFGQGSS YSMMQMLQAA TAVASDGKMK QPHVIAKITD PNTGKTKKTK VKITGQPISA
ATAKRTREEL RYVIDGENGT GKLYAIPGYD VAGKTGTAQI ADPKTGKYMY GMDNYLFSFM
GMAPADDPKL IMYVTMQQPQ LENGPAGSTG GQAVADIFNP VMKTSLQYMN IKPSTVKKSE
VIKAPVVTDK SVTEAKELLE KKDLAPVIIG SGKKIVQQLP KPGTTLLKGQ RVVMLTEGAM
TMPDMRNWSK DDALKVSEIT GIPFEFQGDG YVKSQNVTKG TTINSKSKIR LKMVSPDKLD
AFNKNNDHKS QSETKKETDV QENEGIGSLL NG
//
