ID D7WDV1_9CORY Unreviewed; 1474 AA.
AC D7WDV1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Putative DNA-directed DNA polymerase {ECO:0000313|EMBL:EFK54332.1};
GN ORFNames=HMPREF0291_11989 {ECO:0000313|EMBL:EFK54332.1};
OS Corynebacterium genitalium ATCC 33030.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=585529 {ECO:0000313|EMBL:EFK54332.1, ECO:0000313|Proteomes:UP000004208};
RN [1] {ECO:0000313|EMBL:EFK54332.1, ECO:0000313|Proteomes:UP000004208}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33030 {ECO:0000313|EMBL:EFK54332.1,
RC ECO:0000313|Proteomes:UP000004208};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFK54332.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACLJ02000003; EFK54332.1; -; Genomic_DNA.
DR STRING; 585529.HMPREF0291_11989; -.
DR eggNOG; COG0749; Bacteria.
DR eggNOG; COG4643; Bacteria.
DR HOGENOM; CLU_255102_0_0_11; -.
DR OrthoDB; 5196455at2; -.
DR Proteomes; UP000004208; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:EFK54332.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EFK54332.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004208};
KW Transferase {ECO:0000313|EMBL:EFK54332.1}.
FT DOMAIN 1242..1431
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..892
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1474 AA; 160314 MW; 0758FCDAAB32FC3E CRC64;
MDTKKKTPVG SGGQTEFSQN QDAEVSASND TVMVSDGQAD DTDSCEYTVT PKLTDEHLDE
LRSSAISDDV IESSGIYSAR TVEAVPAPLR YLAENNPAAL PMLVVPMEEV GAGTTYQVKP
QPGSVCDSKG RPKKYVGPAK DNEWGTPPPA LTVLRAVTDD TKRVCIVEGA KQAFAALSHT
DETTAVYRIA GIWSWKGMQN YAVLAQFMDL PVYIIPDADA STNRYVYDGA REFRELLVQW
GATPVRFVQV PGRDKQGLDD VLAEMPEDSR AKMLDMWVDK AQDKPARKMP KMPELDESET
IAEVLEEKLD ENNLRHTTVI DCNEGTPQAR REMMLQAVYK MHGRKSLFRQ ENTAVEMLPR
TEPEEIFEVT DGKSQPEDNR RAIVKVTRAN GLSLICDAVT LYYTTKHSVQ FVDPTTKDID
TIFQPKWAKQ LPHLNGLVFT PIVTPSGRLV LTSEFEPETG LFVDLDDDVA DLDIPENPTD
EDVAWAKERL EDLFCDFPLK TPQDLSRVMA LIMSMVFRPS VSISPAFLFS GSGPAVGKGM
MASAVSTLVT GAPVPVTKCP SKDDEFEKVL TAMLIQGKTL VMFDEPGGVI DSKALAAAIT
EKTHSGRVLG ESRTVSVPNV MQMIFAGNNV AVSRDLARRF VYIDLVVQSD FAEARSGFKY
PQLNAYIKEH RRELMTAVLT LVQAWIAAGR PLPRDGMPTG GFEQWYKCVG GVLTHVGYGD
FMDGVAEQRR VRNDGELADI LHLYWLYTKV QGSGDYPNGF RGYDIQQIIA KIKEQDDLDS
ADTAWAKLGM DDPHVPLPAD IYGTDDARAF ALERAYLSLN NRTLEGLAIE SLEVPKYAER
RFKVVWRGKP EDDPLGGGGP LGGGDDGDDG GTPPPSPAPT PAPAPAPAAD EPVAPAAPAD
STTVVFDLET GSADDQHVTD DPGFVRLATY SVGGAEPVAT TDIAGELIPL LEQADTIVGH
NIVQYDLPVL QRLYGLDVGA LIKAGKVRDT LIMVRLASGG NRNLEYNLDA VAHRCGVDGK
LLAGSESALK ALAKQYGGFD KIPVDNPEYV EYALQDVRAN GAVYEKLLPA TIEAVGEDYL
RREHEKMHSL SVVESHGVRV DTAKVDAFIA EEAQTKAEIR AWLVDTVGIP DEGKAPWASA
AGKQAIAEYL ERFGVAAPRT AKGAISTSAK ALNDLAEAHA DVPEVVELAA KMETLLQSST
PATTIKKYLR GERVYPHITS SQATGRLSTT NPGMTVFGSR DERLIRQREM IVADSADEEL
ISVDLSQIDA RCMAAGSGDA AYAALFAPGR DAHTEMAIRV FGDAARRSDA KALGHAANYG
MGPKSFAAHA GISEVEAKEQ LDRLHFEFPQ LEAFKDHLRK HAKALGWIAT GFGRRVAVDR
AKAYTQAPAA YGQGTARDVF LEGVLNLPAE VLEMVRIFVH DEIVLSVPRE RAEDIKQTVM
DAFKAVTLPC KGDVDVPVLS DSAGPAESWA GCKD
//