ID D8F698_9DELT Unreviewed; 638 AA.
AC D8F698;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=ATP-dependent DNA helicase, RecQ family {ECO:0000313|EMBL:EFK08716.1};
DE EC=3.6.1.- {ECO:0000313|EMBL:EFK08716.1};
GN ORFNames=NPH_2171 {ECO:0000313|EMBL:EFK08716.1};
OS delta proteobacterium NaphS2.
OC Bacteria; Deltaproteobacteria.
OX NCBI_TaxID=88274 {ECO:0000313|EMBL:EFK08716.1, ECO:0000313|Proteomes:UP000003834};
RN [1] {ECO:0000313|EMBL:EFK08716.1, ECO:0000313|Proteomes:UP000003834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NaphS2 {ECO:0000313|EMBL:EFK08716.1,
RC ECO:0000313|Proteomes:UP000003834};
RX PubMed=21124915; DOI=10.1371/journal.pone.0014072;
RA Didonato R.J., Young N.D., Butler J.E., Chin K.J., Hixson K.K., Mouser P.,
RA Lipton M.S., Deboy R., Methe B.A.;
RT "Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of
RT Differential Gene Expression during Anaerobic Growth on Naphthalene.";
RL PLoS ONE 5:E14072-E14072(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFK08716.1}.
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DR EMBL; ADZZ01000356; EFK08716.1; -; Genomic_DNA.
DR AlphaFoldDB; D8F698; -.
DR OrthoDB; 9760034at2; -.
DR Proteomes; UP000003834; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd18018; DEXHc_RecQ4-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EFK08716.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EFK08716.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000003834}.
FT DOMAIN 23..191
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 214..376
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 638 AA; 72305 MW; A17F16A2E62407C1 CRC64;
MKDYFIKRYF GFDRFLDGQK DVIDRIIAGE SAAAIFPTGA GKSLCYQLPA MHLPGMTLVV
SPLLSLMKDQ LAFLTSKRIP AAKLDSTISR EEYQATLRDG VQNKIKILMV SVERFKNERF
RNHLRRMKIS LLVVDEAHCI SEWGHNFRPD YLKIPLYRKE FNIPQVLLLT ATATPKVAKD
MCGKFRIPRG NVITTGFFRE NLHISVASVA ENQKNVALMK VLKEEPAGPS IVYVTLQKTA
EAVAQYLSSA GFDARPYHAG MKTPLREEIQ NHFMNGRLNT VVATIAFGMG IDKGNIRKVI
HYDLPKSIEN YSQEIGRAGR DGLAAACTLL GNRGNIPVLE NFVYGDTPET SGIRYVLETI
AKNDGNMFEV RLNRLSMDAD IRLLPLKTLL VYLEMDGILK PQYTYFETYQ FKMLKTENKI
LDFFSGERRR FVGTIFRHTK KARVWCHPEI SEIVEASGSN RRRVLSALEY FDEKGWIELN
AKSSVEVFEI LNPGFDVEKA SRRLSDLFRN KETMDIGRIQ KMISLFESSR CLAMELSGHF
GENISKPCGN CSFCRTGEPS IFWVEPLPVV SGNDVAEALR GLRTASETSV SDDLDLAARF
FCGILSPRLI QLKAKKRRGF GMLEKYPYQE VKARLQNS
//
