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Database: UniProt
Entry: D8FAU4_9DELT
LinkDB: D8FAU4_9DELT
Original site: D8FAU4_9DELT 
ID   D8FAU4_9DELT            Unreviewed;       438 AA.
AC   D8FAU4;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   08-MAY-2019, entry version 30.
DE   SubName: Full=Homoserine dehydrogenase {ECO:0000313|EMBL:EFK07084.1};
DE            EC=1.1.1.3 {ECO:0000313|EMBL:EFK07084.1};
GN   ORFNames=NPH_7061 {ECO:0000313|EMBL:EFK07084.1};
OS   delta proteobacterium NaphS2.
OC   Bacteria; Proteobacteria; Deltaproteobacteria.
OX   NCBI_TaxID=88274 {ECO:0000313|EMBL:EFK07084.1, ECO:0000313|Proteomes:UP000003834};
RN   [1] {ECO:0000313|EMBL:EFK07084.1, ECO:0000313|Proteomes:UP000003834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NaphS2 {ECO:0000313|EMBL:EFK07084.1,
RC   ECO:0000313|Proteomes:UP000003834};
RX   PubMed=21124915; DOI=10.1371/journal.pone.0014072;
RA   Didonato R.J., Young N.D., Butler J.E., Chin K.J., Hixson K.K.,
RA   Mouser P., Lipton M.S., Deboy R., Methe B.A.;
RT   "Genome Sequence of the Deltaproteobacterial Strain NaphS2 and
RT   Analysis of Differential Gene Expression during Anaerobic Growth on
RT   Naphthalene.";
RL   PLoS ONE 5:E14072-E14072(2010).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFK07084.1}.
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DR   EMBL; ADZZ01000580; EFK07084.1; -; Genomic_DNA.
DR   RefSeq; WP_006424232.1; NZ_ADZZ01000580.1.
DR   EnsemblBacteria; EFK07084; EFK07084; NPH_7061.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; DPRO88274:G10W7-2048-MONOMER; -.
DR   Proteomes; UP000003834; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000003834};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2};
KW   Oxidoreductase {ECO:0000313|EMBL:EFK07084.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003834}.
FT   DOMAIN      357    432       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       9     16       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    207    207       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     107    107       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     192    192       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   438 AA;  46904 MW;  FB83410A732DC7A9 CRC64;
     MKQINVGIIG FGTVGAGTYE VLTTNREIIT NRVGGEVVVR RIADLDIETD RGVPDKPDPA
     ILTTNAMDLI LDPEIDVVVE LMGGLEKARE FILKAMENGK HVVTANKALL AEFGWEIYRA
     AERAGVTLAF EASVGGGIPI IGALKTGLSG NRIQACMGIL NGTSNYILTK MAQENLSFEA
     AVEAAVTLGF AEDPPTLDVD GTDAAHKLAI MISIAFGSAV DFGHVFREGI VAITPDDIRY
     AREFGYHIKL LAIAKDLGDQ LEARVHPVMI PKDHILANVH EAFNAIFLEG DFVGPTLYYG
     LGAGRRPTGS AVVSDIISLA RDVVMEKRGM VPPLGHVQPP GKAVSIQPMD ALVTSYYFRV
     SALDTTGVLS TISGILAQNG ISISSVIQKG RDRKGSVPIV MLTHEARESQ AQQAIRLIDE
     LDVVTDKTVV IRVEGNDL
//
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