ID   D8FT65_9CYAN            Unreviewed;       517 AA.
AC   D8FT65;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=OSCI_10022 {ECO:0000313|EMBL:CBN53555.1};
OS   Kamptonema sp. PCC 6506.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Microcoleaceae; Kamptonema.
OX   NCBI_TaxID=272129 {ECO:0000313|EMBL:CBN53555.1, ECO:0000313|Proteomes:UP000004532};
RN   [1] {ECO:0000313|Proteomes:UP000004532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6506 {ECO:0000313|Proteomes:UP000004532};
RX   PubMed=20675499; DOI=10.1128/JB.00704-10;
RA   Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O.;
RT   "The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506
RT   reveals several gene clusters responsible for the biosynthesis of toxins
RT   and secondary metabolites.";
RL   J. Bacteriol. 192:5264-5265(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; CACA01000001; CBN53555.1; -; Genomic_DNA.
DR   RefSeq; WP_007352786.1; NZ_CACA01000001.1.
DR   AlphaFoldDB; D8FT65; -.
DR   REBASE; 28638; M.Osp6506ORF10022P.
DR   OrthoDB; 9815272at2; -.
DR   Proteomes; UP000004532; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004532};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          24..212
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   517 AA;  57902 MW;  72BF2B4EE153AD65 CRC64;
     MNVTATIELT RMLRQSQLDG ARTQAQRNKL GQFATPPTLA ADILKYASML LPSDIKIRFL
     DPAFGTGSFY SALLQQFGRS QIVKAVGYEI DPHYGNEAIK LWSDTSLHLN IADFTQATPP
     NSDEAKANLV ICNPPYVRHH HLNRVEKLRL QQLAQQTAGV KLSQLASLYC HFLCIADASM
     AVDGLAGWLI PSGFMDVNYG RQIKDYLLNR VTLLRIHCFD AADAQFEDAL CTSAVVWFKK
     ALPPANHAVE FTYGGSLTAS KMSLIVSVES LRSAAKWTKF GLMSGSVNSQ EQPLKLKDLF
     TIKRGLATGA NDFFVLTLEQ VSAYKLPFEF LKPVLPSPRL LSVDEIEGDR LGNPILDRRL
     FLLSCDLPPD EVKAKYPSLW EYLEMGVEQE ICDRYLCKHR SPWYSQEKRP PSPFLCTYMG
     RQDTGRGRPF RFILNHSMAT ATNVYLMLYP KPALAKVLLD RPELLKEVWQ ALDQISDEAL
     MGEGRVYGGG LHKLEPRELG NSLAAKVVEV LSKQLVD
//