ID D8FWP9_9CYAN Unreviewed; 912 AA.
AC D8FWP9;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=PAS domain S-box protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OSCI_1090019 {ECO:0000313|EMBL:CBN54789.1};
OS Kamptonema sp. PCC 6506.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Microcoleaceae; Kamptonema.
OX NCBI_TaxID=272129 {ECO:0000313|EMBL:CBN54789.1, ECO:0000313|Proteomes:UP000004532};
RN [1] {ECO:0000313|Proteomes:UP000004532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6506 {ECO:0000313|Proteomes:UP000004532};
RX PubMed=20675499; DOI=10.1128/JB.00704-10;
RA Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O.;
RT "The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506
RT reveals several gene clusters responsible for the biosynthesis of toxins
RT and secondary metabolites.";
RL J. Bacteriol. 192:5264-5265(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; CACA01000105; CBN54789.1; -; Genomic_DNA.
DR RefSeq; WP_007354014.1; NZ_CACA01000105.1.
DR AlphaFoldDB; D8FWP9; -.
DR OrthoDB; 436222at2; -.
DR Proteomes; UP000004532; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd12913; PDC1_MCP_like; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR029151; Sensor-like_sf.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF08448; PAS_4; 2.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004532};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 377..429
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 573..645
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 647..700
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 736..863
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 684..711
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 912 AA; 103068 MW; 4A09F5C874039055 CRC64;
MLLKALTRRI AKGSQKIPLR LVLVVPFVLQ IFGTVGLTGY ISLRNGQIAV NDVAQQLQVE
IGVRIEQMLT HYLQLPIVIN RINVNAMKLN QLNTKDTSSM TRHFWNQRLL FDSVKISAIY
FGSNEGEFFG LGWQDNQSWQ IGRSGKQTKS RFHSYAIDNE GNPTTLLEVG NVYDPRRRPW
YKKAVAVGKS VWSEIYIDFK EPRLKITLAQ PIYNNLGKLG GVVGVDFILS DIQDFLKSIK
IGKTGHTFII ERSGLLVASS TDQQLFTRDK NGKIKERIQA KDSSTLVIKA TAEYLNSQKE
KLTKINSVQH FIFEIDGTKQ FLQVTPLKDA RGIDWLIIIV VPESDFMEQI HANTRTTIWL
CLGALIVATA LGIFTAHWIT APILRLSEAT QALAKGELDR KVKEKGTREL KVLASSFNQM
AHQLKKTFAT LEKTNEILEA KVKKRTAALT ESELQNRAIL AAIPDLMIRL SKEGVYLEFI
PSKDSEAILL VNNDRIGKHI SEVLPPDIAE LQLQYINRTI ATGETQIYEH QFWSGGQLCE
QEVRIVVSRT NEVLLIVRDI TERKRLEREL SQTSRFLNSI VENIPLALFV KDVKDDFRYV
LWNRAAEKVY SIPRNQVIGH TIYNFMNIEI AASVQSEHQT IIEGGKLIVD EEIFNSKFKG
NIWQRIMKLP LINEQGEVTH LMYIAEDITE RKQAEEALRI AQEQSERLLL NILPKTIADK
LKQNQSAIAE QFEEATILFA DIVGFTPLSA RTPPIELVSL LNHIFSTFDE LAELHGLEKI
KTIGDAYMVA GGLPVPMEFH AEAVAQMALD MQTAIARFQA EKGQPFQIRI GINTGAVVAG
VIGIKKFIYD LWGNTVNIAS RMESQGIPGR IQVTNATYKR LKDKYLFEER GAIAIKGKGE
MITYWLTGKK VD
//
