ID   D8G5B2_9CYAN            Unreviewed;       290 AA.
AC   D8G5B2;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE            EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
GN   ORFNames=OSCI_3520022 {ECO:0000313|EMBL:CBN57802.1};
OS   Kamptonema sp. PCC 6506.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Oscillatoriales; Microcoleaceae; Kamptonema.
OX   NCBI_TaxID=272129 {ECO:0000313|EMBL:CBN57802.1, ECO:0000313|Proteomes:UP000004532};
RN   [1] {ECO:0000313|Proteomes:UP000004532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6506 {ECO:0000313|Proteomes:UP000004532};
RX   PubMed=20675499; DOI=10.1128/JB.00704-10;
RA   Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O.;
RT   "The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506
RT   reveals several gene clusters responsible for the biosynthesis of toxins
RT   and secondary metabolites.";
RL   J. Bacteriol. 192:5264-5265(2010).
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00001937};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily.
CC       {ECO:0000256|ARBA:ARBA00009263}.
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DR   EMBL; CACA01000316; CBN57802.1; -; Genomic_DNA.
DR   RefSeq; WP_007356994.1; NZ_CACA01000316.1.
DR   AlphaFoldDB; D8G5B2; -.
DR   OrthoDB; 643791at2; -.
DR   Proteomes; UP000004532; Unassembled WGS sequence.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR   PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:CBN57802.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004532}.
FT   DOMAIN          5..286
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
SQ   SEQUENCE   290 AA;  32785 MW;  2D3594843D5842D8 CRC64;
     MNAIIFGANG QDGFYLNELC KAKGINPIGL SRSGDWMRGD ISNYEQVEHF IKEYKPTYVF
     HLAAKSTTRH DALFENHAAI STGTLNILEA VYKYSSNSKV FITGSGVQFY NDGNPISEDT
     PFEASSTYAI ARIQSVYAAR YYRSLGIKAY VGYLFHHESP LRKPTHVSQK VVLAAKRIVE
     GADEKLQMGD ISVEKEWTFA GDVAQGIITL VEQENVFEAV IGSGKIHTIK DWIEVCFSIL
     GLDWRRYVEQ TENFQTEYKR LVSNPALMHS LHWRPNIDLQ QLAAMMIEAR
//