ID D8I9W0_BRAP9 Unreviewed; 788 AA.
AC D8I9W0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=BP951000_0068 {ECO:0000313|EMBL:ADK30077.1};
OS Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC Brachyspira.
OX NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK30077.1, ECO:0000313|Proteomes:UP000000332};
RN [1] {ECO:0000313|EMBL:ADK30077.1, ECO:0000313|Proteomes:UP000000332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT "The complete genome sequence of the pathogenic intestinal spirochete
RT Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL PLoS ONE 5:E11455-E11455(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00560}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002025; ADK30077.1; -; Genomic_DNA.
DR AlphaFoldDB; D8I9W0; -.
DR STRING; 759914.BP951000_0068; -.
DR KEGG; bpo:BP951000_0068; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_009320_0_0_12; -.
DR InParanoid; D8I9W0; -.
DR Proteomes; UP000000332; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000332}.
FT DOMAIN 1..112
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 132..414
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 788 AA; 93049 MW; C47E46888DC7DAA7 CRC64;
MGVYSHEDMI SKAIEALENN TINKEIRDNI NTVILDEAQD TSKLQFSFIN LIVFGNREIT
KETTIKDKKI LIVGDRKQSI YRFRNADLNV FRNAQNIFED YVRYLQDNYR SKEMLINFFN
DIFENTIFKD DTIKYKKDDN LISGQNDNTK SKLVSLLVFN NNIDDDIKLN SDSKTILEAY
AIAKFIKTNL KNDYKNTAIL LQTFSRLNIY LSVFAEEKIP YYVDGGNGFY DRVEISNLII
CLKYLVLKDY SLLQSLLMSE LFDIKIANLY DFSIDLKLNG NYNLYDYFSL NDCKEKTLEI
AKKKKYYDEL KKAKELLNNI ELKISTMSSY DAIETICTET NYYNYLMLKE DAEISYANIE
KLKKLAYDFE NRAGVNIYDF VISLDMNAKD ISYATIPKLS VDAIRIMTIH KSKGLEFNNV
FLAGAGHYRA AQNNMFDFVE NFPYIEIPIH GEIEEKLKFF SKDDNYNSLA DKSEKKRLLY
VALTRAKERL IISGEDRYKR FDDPKSYRNY IEAYHHFDIE DSVDNTTDDL IYIDDNTNEF
MDYYSYGISK NTNYDLNELY INNLEKINKK IDSININDTI SEKTKKIEYV NPSEVLDTDF
DKNIISRLLN KNISISLNDD KKFDLENLET IKAIDMGILM HNLLEHFNFD EYKLHKESYI
EKIKNDTIKQ NKHYDEKDLR KKLDKYFTNF INNKHIANII NGEELIVSRE HKFQERKLIE
NRTQIINAKI DIITKNISEE YFILDYKTTK YSKEKEDKYK TQLEMYRDIV KKTFDINSEI
YIDLIFLG
//
