ID D8IB79_BRAP9 Unreviewed; 532 AA.
AC D8IB79;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Potassium proton antiporter {ECO:0000313|EMBL:ADK30402.1};
GN OrderedLocusNames=BP951000_0397 {ECO:0000313|EMBL:ADK30402.1};
OS Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC Brachyspira.
OX NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK30402.1, ECO:0000313|Proteomes:UP000000332};
RN [1] {ECO:0000313|EMBL:ADK30402.1, ECO:0000313|Proteomes:UP000000332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT "The complete genome sequence of the pathogenic intestinal spirochete
RT Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL PLoS ONE 5:E11455-E11455(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002025; ADK30402.1; -; Genomic_DNA.
DR RefSeq; WP_013243357.1; NC_014330.1.
DR AlphaFoldDB; D8IB79; -.
DR STRING; 759914.BP951000_0397; -.
DR GeneID; 56438976; -.
DR KEGG; bpo:BP951000_0397; -.
DR eggNOG; COG3263; Bacteria.
DR HOGENOM; CLU_005912_9_1_12; -.
DR InParanoid; D8IB79; -.
DR Proteomes; UP000000332; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000332};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 397..481
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 483..532
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 532 AA; 58605 MW; 166DF11623EA0CAC CRC64;
MNTAILISSL IIIICIVASK ISMKVGVPSL LLFLVLGMLF GSDGILKIEF DNYVVAEQIC
TITLIFIMFY GGFGTNWKVA KPVAKKAFLL SFVGTFITSM VTGVLCYFVL KFELFESFLI
ASVIGSTDAA SVFSILRSKN LNLKDGLASL LELESGSNDP MSYMLTVIFL GLIGKTLNSP
LSIVYMVFAQ IVFAVIVAAL ISFMAYNVLR KFKFPVSGLD TIFVLAVALL SYSLSSIVGG
NGYLAVYLVG IVLGNSSIKN KVALVNFFDG VTGLMQMVLF FLLGLLSFPS RISNVAPTAI
FVALFITFVS RPIAVLAILT PFRVSLKKQL LIMWAGLRGA ASIVFAIFVI VNGEAISYDI
FHIVFFLAII SVSFQGTLLP IIAKKLGLVD SAENVLKTFN DYVDDDDMEL IQVNITKNHH
WVGREIKDIE LPENSIIITI ERGDETIIPN GSTVINSGDT IILNAKRTKY YDITLKEINI
NINHPWKNKE LKDLKLPKDN LIVMIKRDGG TIIPRGNTMI KYRDVLLMRN ND
//
