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Database: UniProt
Entry: D8IFM8_BRAP9
LinkDB: D8IFM8_BRAP9
Original site: D8IFM8_BRAP9 
ID   D8IFM8_BRAP9            Unreviewed;       332 AA.
AC   D8IFM8;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   RecName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00014165, ECO:0000256|PIRNR:PIRNR005096};
DE            EC=5.1.3.3 {ECO:0000256|ARBA:ARBA00013185, ECO:0000256|PIRNR:PIRNR005096};
GN   Name=galM {ECO:0000313|EMBL:ADK31951.1};
GN   OrderedLocusNames=BP951000_1973 {ECO:0000313|EMBL:ADK31951.1};
OS   Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000).
OC   Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC   Brachyspira.
OX   NCBI_TaxID=759914 {ECO:0000313|EMBL:ADK31951.1, ECO:0000313|Proteomes:UP000000332};
RN   [1] {ECO:0000313|EMBL:ADK31951.1, ECO:0000313|Proteomes:UP000000332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1826 / 95/1000 {ECO:0000313|Proteomes:UP000000332};
RX   PubMed=20625514; DOI=10.1371/journal.pone.0011455;
RA   Wanchanthuek P., Bellgard M.I., La T., Ryan K., Moolhuijzen P., Chapman B.,
RA   Black M., Schibeci D., Hunter A., Barrero R., Phillips N.D., Hampson D.J.;
RT   "The complete genome sequence of the pathogenic intestinal spirochete
RT   Brachyspira pilosicoli and comparison with other Brachyspira genomes.";
RL   PLoS ONE 5:E11455-E11455(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC         ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001614,
CC         ECO:0000256|PIRNR:PIRNR005096};
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC       {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC   -!- SIMILARITY: Belongs to the aldose epimerase family.
CC       {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
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DR   EMBL; CP002025; ADK31951.1; -; Genomic_DNA.
DR   RefSeq; WP_013244900.1; NC_014330.1.
DR   AlphaFoldDB; D8IFM8; -.
DR   STRING; 759914.BP951000_1973; -.
DR   GeneID; 56440528; -.
DR   KEGG; bpo:BP951000_1973; -.
DR   eggNOG; COG2017; Bacteria.
DR   HOGENOM; CLU_031753_1_0_12; -.
DR   InParanoid; D8IFM8; -.
DR   OMA; ATWLSCK; -.
DR   UniPathway; UPA00242; -.
DR   Proteomes; UP000000332; Chromosome.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09019; galactose_mutarotase_like; 1.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR018052; Ald1_epimerase_CS.
DR   InterPro; IPR015443; Aldose_1-epimerase.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR047215; Galactose_mutarotase-like.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR   PANTHER; PTHR10091:SF0; GALACTOSE MUTAROTASE; 1.
DR   Pfam; PF01263; Aldose_epim; 1.
DR   PIRSF; PIRSF005096; GALM; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000332}.
FT   ACT_SITE        171
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT   ACT_SITE        296
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT   BINDING         73..74
FT                   /ligand="beta-D-galactose"
FT                   /ligand_id="ChEBI:CHEBI:27667"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT   BINDING         171..173
FT                   /ligand="beta-D-galactose"
FT                   /ligand_id="ChEBI:CHEBI:27667"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT   BINDING         234
FT                   /ligand="beta-D-galactose"
FT                   /ligand_id="ChEBI:CHEBI:27667"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ   SEQUENCE   332 AA;  37926 MW;  F3615E71C6DE28FC CRC64;
     MQVKNFNNGY LLYELKNKND MVLKLTDIGA SIVGVFVKDK NNNDVQVSFG SDDINFYLQP
     HDYIGASVGR VANRTIDAEF TLDGVTYKLA KNDNNKHHLH GGVEGISFKK FDSKCINDKS
     VLFSYFSKDG EEGYPGNVNI NITYTLTDDN EIIIDYFANT DKKTPLNFTN HAYWNLNGDG
     TIYEHELFID SKYYLPVTDE CVSTGEILKT ENTPFDFTKN KKVGLDIEKC GGYDNCFIFA
     NNDINKLKAK AYSEKTGISL EFYTTQPAMH FYSGNMLNNR EVRNTVLNKH MAFCFESEYL
     PGALNFLHFP SIIYSPDKDY KERTIYKLSL NK
//
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