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Database: UniProt
Entry: D8IVY3_HERSS
LinkDB: D8IVY3_HERSS
Original site: D8IVY3_HERSS 
ID   D8IVY3_HERSS            Unreviewed;       805 AA.
AC   D8IVY3;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   08-MAY-2019, entry version 48.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein {ECO:0000313|EMBL:ADJ61781.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:ADJ61781.1};
GN   Name=fadB {ECO:0000313|EMBL:ADJ61781.1};
GN   OrderedLocusNames=Hsero_0255 {ECO:0000313|EMBL:ADJ61781.1};
OS   Herbaspirillum seropedicae (strain SmR1).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Herbaspirillum.
OX   NCBI_TaxID=757424 {ECO:0000313|EMBL:ADJ61781.1, ECO:0000313|Proteomes:UP000000329};
RN   [1] {ECO:0000313|EMBL:ADJ61781.1, ECO:0000313|Proteomes:UP000000329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SmR1 {ECO:0000313|EMBL:ADJ61781.1,
RC   ECO:0000313|Proteomes:UP000000329};
RA   Pedrosa F.O., Monteiro R.A., Wassem R., Cruz L.M., Ayub R.A.,
RA   Colauto N.B., Fernandez M.A., Fungaro M.H.P., Grisard E.C.,
RA   Hungria M., Madeira H.M.F., Nodari R.O., Osaku C.A., Petzl-Erler M.L.,
RA   Terenzi H., Vieira L.G.E., Almeida M.I.M., Alves L.R., Arantes O.M.N.,
RA   Balsanelli E., Barcellos F.G., Baura V.A., Binde D.R., Campo R.J.,
RA   Chubatsu L.S., Chueire L.M.O., Ciferri R.R., Correa L.C.,
RA   da Conceicao Silva J.L., Dabul A.N.G., Dambros B.P., Faoro H.,
RA   Favetti A., Friedermann G., Furlaneto M.C., Gasques L.S.,
RA   Gimenes C.C.T., Gioppo N.M.R., Glienke-Blanco C., Godoy L.P.,
RA   Guerra M.P., Karp S., Kava-Cordeiro V., Margarido V.P., Mathioni S.M.,
RA   Menck-Soares M.A., Murace N.K., Nicolas M.F., Oliveira C.E.C.,
RA   Pagnan N.A.B., Pamphile J.A., Patussi E.V., Pereira L.F.P.,
RA   Pereira-Ferrari L., Pinto F.G.S., Precoma C., Prioli A.J.,
RA   Prioli S.M.A.P., Raittz R.T., Ramos H.J.O., Ribeiro E.M.S.F.,
RA   Rigo L.U., Rocha C.L.M.S.C., Rocha S.N., Santos K., Satori D.,
RA   Silva A.G., Simao R.C.G., Soares M.A.M., Souza E.M., Steffens M.B.R.,
RA   Steindel M., Tadra-Sfeir M.Z., Takahashi E.K., Torres R.A.,
RA   Valle J.S., Vernal J.I., Vilas-Boas L.A., Watanabe M.A.E., Weiss V.A.,
RA   Yates M.A., Souza E.M.;
RT   "The genome of Herbaspirillum seropedicae SmR1, an endophytic,
RT   nitrogen-fixing, plant-growth promoting beta-Proteobacteria.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP002039; ADJ61781.1; -; Genomic_DNA.
DR   STRING; 757424.Hsero_0255; -.
DR   EnsemblBacteria; ADJ61781; ADJ61781; Hsero_0255.
DR   KEGG; hse:Hsero_0255; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1024; LUCA.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000264370; -.
DR   KO; K07516; -.
DR   OMA; GQGFYKK; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000000329; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000329};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296,
KW   ECO:0000313|EMBL:ADJ61781.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000329}.
FT   DOMAIN       18    199       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      204    303       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   805 AA;  87246 MW;  FE6D791479FE2B42 CRC64;
     MFAAPAKESC VSNFIVKKVA VLGAGVMGAQ IAAHCINARV PVVLFDLPAK EGPKNGIVQR
     AIENLKKLSP APLGNKDDAA LIQVANYEDD LAVLEGCDLI IEAIAERMDW KHDLYKKVAP
     HIGPKAIFAS NTSGLSINAL SEGFDAGLKA RFCGVHFFNP PRYMHLVELI PTQSTEPHIL
     DQLEAFLTTT LGKGVVRAFD TPNFVANRVG VFGILATIIE AEKYGLSVDV VDDLTGAKLG
     RAKSGTFRTA DVVGLDTMGH VIRTMQDNLK DDPFFSSYAT PPLLAKLVEQ GALGQKSGAG
     FYKKVGKDIL RIDPAKGDYV PGGAKADDII ARILKEKDPV KRMKALHDST NPQGQFLWAI
     FRDAFHYIAV HLESVADNAR DLDFAMRWGF GWSVGPFETW QAAGWKQIAQ WVKEDIDAGK
     ALSTAPLPDW VFDGRDGVHS EKGSYSPSKK ADVARSELPV YQRQAFRAPL VGEGAADGKS
     AGTTFFEDES VRIWHQNDDV LILSFKTKMH VIGQGVIDGM NKAVSEAEQN FKGLVIWHPD
     AAEGGAFSAG ADLQSMLPLF MSGGVKAIEP VVHQLQQAHQ RLKYASVPVI AAVAGLALGG
     GCELLLHTAK RVVSIESYIG LVEVGVGLIP AGGGLKEAAV RAAREAKGND ILPFLKEYML
     AAATANVSKS ALEARKLGYL REDDVIVFNP YELLHVAKVE ARALFDAGYR PQLPPQVPVI
     GRNGLATIMA QLVNMRDGGF ISAHDFKLGK MIAETVSGGE VEEGSIVNEQ WLLDIERKFF
     MELLNHPKTQ ERIMGMMQTG KPVRN
//
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