ID D8JPS9_HYPDA Unreviewed; 890 AA.
AC D8JPS9;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=MscS Mechanosensitive ion channel {ECO:0000313|EMBL:ADJ23813.1};
DE Flags: Precursor;
GN OrderedLocusNames=Hden_2012 {ECO:0000313|EMBL:ADJ23813.1};
OS Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIMB 11706 /
OS TK 0415).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=582899 {ECO:0000313|EMBL:ADJ23813.1, ECO:0000313|Proteomes:UP000002033};
RN [1] {ECO:0000313|Proteomes:UP000002033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415
RC {ECO:0000313|Proteomes:UP000002033};
RX PubMed=21705585; DOI=10.1128/JB.05453-11;
RG US DOE Joint Genome Institute;
RA Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL J. Bacteriol. 193:4567-4568(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP002083; ADJ23813.1; -; Genomic_DNA.
DR AlphaFoldDB; D8JPS9; -.
DR STRING; 582899.Hden_2012; -.
DR KEGG; hdn:Hden_2012; -.
DR eggNOG; COG3264; Bacteria.
DR HOGENOM; CLU_011796_1_0_5; -.
DR OMA; RATEIQM; -.
DR Proteomes; UP000002033; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR022249; DUF3772.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF12607; DUF3772; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002033};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..890
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003116308"
FT TRANSMEM 310..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..294
FT /note="DUF3772"
FT /evidence="ECO:0000259|Pfam:PF12607"
FT DOMAIN 720..786
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 794..874
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 18..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..104
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..136
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 890 AA; 94868 MW; 9927E7C54385BF94 CRC64;
MLKHVFAAVV ALALAAPSAE AKPGTPNWTS TTTPAAGQAA AQAQPAAPAP NQAAPAAPAP
APQPAKAQPA PVAQTAPAPQ PAAGQPAAAP QPAAPQPAAP AADAAPPASP DAVPGEPAAA
ETPPPPPPPP KPAPVLSPEV NDAITVMVDS MDTAEKRLSG ISAANDTLSE LRDQIDSVIA
QATKTADSIR PRQDEIDRQL SKLGPPPAKD APPESATVAA ERVRLAVQST ELDEATKTLR
VTWWRARQAI DKITNLRLSF FVKNLTERIT SPLFPQFWTD LARVAPNVEW RLKYNVNDWT
SSVDKQKTNV AMLIAAVIGL YIFLKGLALA ITRYRPNENA TPPTFFERAA SASWIAPVRA
IPGVAATFLL FGGLHYFGLL YEPTAAPVGG ALLDSALIFV GVSALISAVF APGQPERRLV
LLSSRSARRI SRLIRFLALI YCIDLFLSSF AQVFYFPLAL SVVQSLFTSL AFAFVLIGLL
LTPFEASEAG GLKAVGRHRP LWLKLPLWLA AFAIIGCCLV GYVALGRFLA QQLVMTGVVG
MISTLLYLAI RAFTRGNTTS RGHISVLLEE RMGFDETRRK QLGWLTESLL TLGVILATIP
VLMLQWGFSG ADIRDWSARL LFGFEIGQFR ISLVRILIGI AIFVAFVFVT RLVQRRLRDN
VLVAPRMDPG IANSIDTAVG YAGTGLGAIA AVSYAGFDIT NLAIVAGALS VGIGFGLQSI
VNNFVSGLIL LIERPIKVGD LVVVGGEQGV VKRISVRSTE IETSDRASLI VPNSELVTGR
VLNWTHRNAL GRVVMKFSSG PDTDPRLVLA VLSECANRHP NVMREPAPVA VFEGYSPTTT
DFSLRVLLPD ITHSLRVQSD LRVAIYEALR RAHIGGSEGF AAHPAVSEAS
//