ID   D8JX93_HYPDA            Unreviewed;       138 AA.
AC   D8JX93;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:ADJ23229.1};
GN   OrderedLocusNames=Hden_1417 {ECO:0000313|EMBL:ADJ23229.1};
OS   Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIMB 11706 /
OS   TK 0415).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Hyphomicrobiaceae; Hyphomicrobium.
OX   NCBI_TaxID=582899 {ECO:0000313|EMBL:ADJ23229.1, ECO:0000313|Proteomes:UP000002033};
RN   [1] {ECO:0000313|Proteomes:UP000002033}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415
RC   {ECO:0000313|Proteomes:UP000002033};
RX   PubMed=21705585; DOI=10.1128/JB.05453-11;
RG   US DOE Joint Genome Institute;
RA   Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT   "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL   J. Bacteriol. 193:4567-4568(2011).
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DR   EMBL; CP002083; ADJ23229.1; -; Genomic_DNA.
DR   RefSeq; WP_013215444.1; NC_014313.1.
DR   AlphaFoldDB; D8JX93; -.
DR   STRING; 582899.Hden_1417; -.
DR   KEGG; hdn:Hden_1417; -.
DR   eggNOG; COG0262; Bacteria.
DR   HOGENOM; CLU_1872632_0_0_5; -.
DR   OrthoDB; 7932254at2; -.
DR   Proteomes; UP000002033; Chromosome.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:InterPro.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR001796; DHFR_dom.
DR   Pfam; PF00186; DHFR_1; 1.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002033}.
FT   DOMAIN          6..126
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|Pfam:PF00186"
SQ   SEQUENCE   138 AA;  15555 MW;  72B1013E49A694DB CRC64;
     MEQTVVRVIC AIGQSGQLGH NGVLPWEGNP SPEYVADVAR FFDITRGHVL LAGPKTIASV
     PKFAFADRTI EVLRSHMDPE QTLKHYAGRV VFIGGGPPVW DIYARYVSHW DVTRLPYDGP
     ADRWFNPLWL TCGEHQQR
//