ID D8LBX3_ECTSI Unreviewed; 625 AA.
AC D8LBX3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Lipoxygenase {ECO:0000313|EMBL:CBN79156.1};
GN Name=LOX {ECO:0000313|EMBL:CBN79156.1};
GN ORFNames=Esi_0010_0039 {ECO:0000313|EMBL:CBN79156.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN79156.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN79156.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN647683; CBN79156.1; -; Genomic_DNA.
DR AlphaFoldDB; D8LBX3; -.
DR STRING; 2880.D8LBX3; -.
DR EnsemblProtists; CBN79156; CBN79156; Esi_0010_0039.
DR InParanoid; D8LBX3; -.
DR OrthoDB; 999249at2759; -.
DR Proteomes; UP000002630; Chromosome LG08.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF153; LIPOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..625
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003117021"
FT DOMAIN 303..625
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
FT REGION 70..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 70449 MW; 96ECAAE6CA309807 CRC64;
MPHSRTMKVA VLALVVAMGD AFVAPTPRAN NRPTTRTDRR VETSAVAPLN IAGFSFSSIT
DFFTSNREGV TSLPQDPKAD QAHRKEQLEE RKKEYRWSTE GPPEGTPYLE GFPPDDELPS
VAWTTDLVAS VLKIAVGTLR GSLGAGEIME ALTDPAKAKT FATRVRELIR ENFAIDERPA
DIGDYQDLHA FPIKNPKSMY DWQDDEAFAR LRLQGGNCVV LEKCTQSTRE KLKVLDSDPV
YKKLKSKVDS LMDEGKLFVV DHELLKDMEA YPIEGVERYL TPSVALFEVI DDDLLPIRPI
GIQVVSHLGN THVVLEAPMV AVNRCLPKEH PVYDLLKPHM EGTALINWGA QNLLIQPDNA
VDILQANDIE SSWDLVLEQV LKRIAGDFSP EADFASRQIT KEDFPGRYPY RDYGMRYWEA
THTWVKEYLD IYYKSDKDVE EDYELQAMIE ELVDIGKVYW LKDYYTTDDK KALIAKVIAS
WIYSASTLHA AVNFPQKPSM SFVPSCPGSV YAPPPIDKRE RTFDEFMNYL PPMEIATIHV
AILTLLGDIF HTKLGQYETH NFDDDRIAEP LAKFQQAIED IEDDLVADNA DVVSGWRGRG
KAGKVANNMA YTTLLPDNIP QSINI
//
