ID D8LCZ3_ECTSI Unreviewed; 1339 AA.
AC D8LCZ3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=Esi_0112_0031 {ECO:0000313|EMBL:CBN78360.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN78360.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN78360.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; FN647812; CBN78360.1; -; Genomic_DNA.
DR STRING; 2880.D8LCZ3; -.
DR EnsemblProtists; CBN78360; CBN78360; Esi_0112_0031.
DR eggNOG; KOG0920; Eukaryota.
DR InParanoid; D8LCZ3; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000002630; Chromosome LG02.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA_RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 146..352
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 431..599
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1339 AA; 142923 MW; 178D5A1D0B228DD4 CRC64;
MPGPGGGGGG NFQQRWEGKG NQSKGKAMNV NDMTPEDREA HLAHKAAQKH AQRLADPEPE
KLEVPEQMLK EVYAAAQDVL HAKNDLRGRG SVDEKDGPRA RRREVWGGNG SGVSIPPPPS
HKGAAYEDIQ TSRRKLPAYA RQQDILEAIN NNQVVVISGE TGCGKTTTGG QQVTLVTHRG
SSYGAAVTAG SMLWWHQVPQ FLMDQYRYDG DGGDGGGDGG ASKPYNIVCT QPRRISAIGV
AERVAAERGE AVGGTVGYQI RLERRASEHT KLLFVTTGIL LRRLQADPQL EGVTHVILDE
VHERTVDSDF LIIILRDLVL QRKDLTLVLM SATLNADLFS NYFSQAPKLN IPGYTFPVEE
YYLEDALELT RTQITPTVNR QGRVKRKPLD REQFGQKMSK LEHLRGRYSQ RTLQSMAMFD
ESEVPLDVIV DLVRHVHAYE GEGAILIFLS GWEEISAVHD KLEALPEARA WRLYALHSQM
PTSQQRDVFL RPPRGVRKIV IATNIAESSI TIDDVVYVID GGKHKEKSYD PEAKVQSLLP
AWVSQASSKQ RRGRAGRVQP GRCWHVYPRS KVSEMNEYQL PEIVRTSLES LCLQVRHLGL
AAGGKGGVAG FINKALTPPG VVALDNALTL LTRIGAFRTN ESLTPLGKHL ALLPVEPQIG
KALVLGCMLG CLDPVLTIAA LLSQRNPFVM PMSKKEEADQ AKRRFAQGEP SDHLCLYNAY
EAWRMCPRRD QQEFCHVNFL SPSALRTASD VRGQFQTLLR DAGLIPRDRE QLAELNRHSE
MPKYWPVVRA AMCSGLYPNL VRVDYGKKKF KLLSADHSTL NPHPSSVTSE GNPFNRRWAY
YHEMCRTPGG LFIYDLTEAA PLPLLLFGAG QRDPGRPGQL IHKLVTGPHI QGGGKKKKGK
KKGYQAPPSV GPFAGVEPWV YFDVGRDVRR PLEDIRSALE YVVGEHVGGA RSSERETRLI
NTVAQAFVGE EELANPPKPG GGHDRSQHHH GTMKAYNVDA DDDYEFHRHG HGGSEYRGSG
HGAYRGYGDG SSGANASSSS RGGDGGGGGS GGYGSSSAIG SGGHGGYSRG GGGTGGHYSS
SSYSGGGGGS HVQNGAGYPP YGSSSGGGDR SGDHRGDSGR GGSGGHYGKS SPPLSEKPPS
HSMAGGDVRY AAPQAAPKLG HSSSSMSGGG SSSMSGSAHA GGSFGGYGHY GGVGRSGGGG
GGGGGAGPLG PGGGPARYNP SNGESSGGGG YQGGGRGDPG SVSQPRSLAR PGGVASHEFT
RGPMRPSTHS PVSTVLGGEY HNYAVPPGSA PLGGGSGGGE GGAGHPQHHY VSRSVPMSRG
EDSRDRDGHG GRGGKRGRW
//
