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Database: UniProt
Entry: D8LEB7_ECTSI
LinkDB: D8LEB7_ECTSI
Original site: D8LEB7_ECTSI 
ID   D8LEB7_ECTSI            Unreviewed;       303 AA.
AC   D8LEB7;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   18-SEP-2019, entry version 27.
DE   RecName: Full=IRK domain-containing protein {ECO:0000259|Pfam:PF01007};
GN   ORFNames=Esi_0013_0131 {ECO:0000313|EMBL:CBN74202.1};
OS   Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC   Eukaryota; Stramenopiles; PX clade; Phaeophyceae; Ectocarpales;
OC   Ectocarpaceae; Ectocarpus.
OX   NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN74202.1, ECO:0000313|Proteomes:UP000002630};
RN   [1] {ECO:0000313|EMBL:CBN74202.1, ECO:0000313|Proteomes:UP000002630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX   PubMed=20520714; DOI=10.1038/nature09016;
RA   Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA   Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA   Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C.,
RA   Brownlee C., Carrano C.J., Charrier B., Cho G.Y., Coelho S.M.,
RA   Collen J., Corre E., Da Silva C., Delage L., Delaroque N.,
RA   Dittami S.M., Doulbeau S., Elias M., Farnham G., Gachon C.M.,
RA   Gschloessl B., Heesch S., Jabbari K., Jubin C., Kawai H., Kimura K.,
RA   Kloareg B., Kupper F.C., Lang D., Le Bail A., Leblanc C., Lerouge P.,
RA   Lohr M., Lopez P.J., Martens C., Maumus F., Michel G.,
RA   Miranda-Saavedra D., Morales J., Moreau H., Motomura T., Nagasato C.,
RA   Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F., Pommier C.,
RA   Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA   Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C.,
RA   Segurens B., Strittmatter M., Tonon T., Tregear J.W., Valentin K.,
RA   von Dassow P., Yamagishi T., Van de Peer Y., Wincker P.;
RT   "The Ectocarpus genome and the independent evolution of
RT   multicellularity in brown algae.";
RL   Nature 465:617-621(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; FN647938; CBN74202.1; -; Genomic_DNA.
DR   STRING; 2880.D8LEB7; -.
DR   EnsemblProtists; CBN74202; CBN74202; Esi_0013_0131.
DR   InParanoid; D8LEB7; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000002630; Unplaced LGUn.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002630};
KW   Ion channel {ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM    162    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    225    250       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      189    255       IRK. {ECO:0000259|Pfam:PF01007}.
SQ   SEQUENCE   303 AA;  33532 MW;  0299A12E62419939 CRC64;
     MRQMCTPHTT DGPKHPGATS SAAVFVFRCW WLIDGSAARR YERALHAVSV TYRSIANAPQ
     DEEIGIHGSI SSGGGDTVII PGSTRRHLKP RLILGKAWGR SVKWLKARKK GEQAYRLVDR
     EGPFHQSIGR WNIRRLKTQA DVQKLIGLDP FHSFLNQSTL KIILLIIALY LSLVLLFAIV
     YTTISLTLGC NLQLTSIREG FLFSLETMTT VGYGTHDYLF GSCWIMLPML SLQACIGLLI
     DAFLIGILFA RLSRPQTRAN TVVFTKNAVI RRVRGEAYFM LGSSASTSCW KPVCAATPSA
     TSG
//
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