ID D8LEU4_ECTSI Unreviewed; 1388 AA.
AC D8LEU4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN ORFNames=Esi_0014_0059 {ECO:0000313|EMBL:CBN79764.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN79764.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN79764.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
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DR EMBL; FN648000; CBN79764.1; -; Genomic_DNA.
DR STRING; 2880.D8LEU4; -.
DR EnsemblProtists; CBN79764; CBN79764; Esi_0014_0059.
DR eggNOG; KOG0964; Eukaryota.
DR InParanoid; D8LEU4; -.
DR OMA; DQHQSMR; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000002630; Chromosome LG11.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR CDD; cd03272; ABC_SMC3_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR041741; SMC3_ABC_euk.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 3.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 544..660
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 260..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1309..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 180..214
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 701..798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 879..951
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 379..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1127
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1365
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1388 AA; 155386 MW; B73D9331435EA5CE CRC64;
MHIKQVSMSG FRSFRSQPEI ESFSPRHNVI VGRNGSGKSN FFDAIQFALL NQRFSNLRQE
ERQLLLHEGA GAKLMSAYVE IVFDNSDGRL AQDGDEVVLR RNIGMKKDEF FLNLKRVTKQ
EVSSLLESAG FSKANPYYIV QQGKVSALTL MKDAERLNLL KEVAGTKVYE ERRQESLKIM
DELNNKFEKI QEVISFIEER LGELEEEKEE LGAYQKHDKQ RRALEFALYD KELTKARESL
QDKDRAMEET EYRIRELQER LQHARSQAGH DEKDLADGET AASKLDKQVA AKEAERRELL
GVRAKLELEV KDLSERVATD GDEQERLAEE LKTLDANIAA RKKDLETEAG PAYDKARASV
SATEMELGAA AGQREELYAK QSRGSKYRTA EERDAALKSQ VKSTRLAAKG KSDTAASLKS
QAVKMSEQLD RQRKKAAEME AQLQERHLQS QRVSADLVQR TAARNSLAEE RKEKWRVIEG
LQEGPRRAAG GEVRGRDGGL ARDRISEQKA ALEKSERDLR FAMPRSVASG LDAVEALVKE
QRIEGYYGPV YENFALRDPV LATAVEVAAG NTIFNVIVDN DHTAAKLMHM LERRKLGRVT
FMPLNKLATR MAPRKELGNK VVAYLIEAAI KFRPEVKPAM EQIFGKKLLA KDLETASKYS
ERKECDMDVV TMNGDEFNRK GSISGGYHDE RAGRLLTLEK IRGLRRDLDK LAGERKGMQA
KSNETDQAVT NLLGEVQKLE AKRASIRNVM AQTNKDLGHI KKAAVTTEEQ LHEKEELLEQ
VSREAQQESN KADVLQAEIG TPLMATLTEA DQRTLHELNT VRVPALNARL KTEFDALEVT
AAARTRLLSI LNGNLQRRRE EVRELLDPDR GGIGGSARSG EAEERLETLA QRREELSKAG
RSLEALRVEL EDMEKIASER RQEVSAIRKE VDNMKAEEAR LLERLAEESK VKGKLKGKQE
MCVTQLEDNT QKMQSLGTLP HGQHEQYKTM DTKKLMKKLN AANESLKKFS HVNKKALDQY
VSFSEQRETI LKRKKEIDAA QTAIKELIEG LDLQKDEAIL RTFRGVSQNF SEVFQELVPS
GSGVMVIKTS ADAAATTTKK KGSKNAEEEE EEEEEEEEEE EEEGGDEAGN PGSGKKSSKG
KGKAKAKARE GGEDGAGADE EEPNGLSPTT LVSDFVGVQI KVSFVAAGET FLMSQLSGGQ
KAVVALALIF AIQRCDPAPF YLFDEIDQAL DSSYRAAVAS LIQRQAHSSD NPTQFITTTF
RPEMVAVASQ CYGISHQNKV SNIHVLPRQE ALGFVANIMN EEEAVGVELQ QPASAARQKQ
GGGSRRGSRG AREEEVEEEE EADEMDVEEE EGDDEEEEEE EEEEARRPSL EGKRRRVRSG
GERESSSR
//
