ID D8LK46_ECTSI Unreviewed; 1084 AA.
AC D8LK46;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 22-FEB-2023, entry version 51.
DE SubName: Full=Pleckstrin homology (PH) domain-containing protein {ECO:0000313|EMBL:CBN74515.1};
GN ORFNames=Esi_0028_0149 {ECO:0000313|EMBL:CBN74515.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN74515.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN74515.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648464; CBN74515.1; -; Genomic_DNA.
DR AlphaFoldDB; D8LK46; -.
DR STRING; 2880.D8LK46; -.
DR EnsemblProtists; CBN74515; CBN74515; Esi_0028_0149.
DR eggNOG; KOG0930; Eukaryota.
DR InParanoid; D8LK46; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000002630; Chromosome LG16.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 412..593
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 612..726
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 168..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..353
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 113812 MW; 5119303D710F6635 CRC64;
MPTGCIHHSQ IHSSIDLVDA ASSGSVTATR GGAAELTDEE GEVGPAIGMG WDVEGGQVLK
PPRNSSISTG DACIGCPAAD GAQRKPSIQS PQEASDAALF QHHHACGGAN PDNIPGDGPV
PLAPFGTSAI SIRSGSAAAG VHMHKRGGGG MELEPEAVVV TPLASAGAGD VGAEHDATPL
QSRHKGSARS GGGFGSPRSS SGGGGGGGGG DARGETASDG AASVSGVDDS LSSVGEGPGG
LKRKDTITWE SFLANITVTD EAKEAGGGAK GAEAAAGACS DSSPPVAMRL TSGAASEGVK
GLLGSAAEQP LTARTRYLRA MASNAGDVRW NDDLDDEDRN DDCDGDGDSD GDTESAGLPE
LSEGQLVHRA NVQRLLSDLS DRTFSPRARH PVDLGRSQSM SSVGMGSINS VRKIMERGVN
KFNVNPKDGI AYLIDNGLVT DSAQGICSFL CSAEGLSKRR LGEYFGRDNP KAQEVLRLFL
KELKFKNASL DEALRAMVMR FRLPGEAQQM DRIMESFAVR YHEENPYVFS CSDTAWVLAF
GLMMLNTDMY NRNIKESDKM TEAEFVKNHR GIDQGKDPAK ELLEGMYRRI KASEIRMAEG
DMYESEVITF VAPKKSGWLK KKSTGYVGKW KRHWFVLNDA VLYYFLAPQH QDEAPRCIIP
LEGINISPIG ATDLSIGLRT NQGFVKSVKM ADNGTMQQGT HRSFTLRADT NSERDIWVDA
LRAEVPAFHM ELSASRSLSA TPATSSAPTP IGTPSESGRR SGKFSASGRT RRRATIDLEA
SSKMQPPVIR GWARTQSDQH QSGGRRYIAL FRDIGPDQQD NVIYFFGDAA MCDKMIEQHL
RTSHGSLNLS DVTRVQLQQE EGGGGGRAIA LQTGAGKHVK EVVIVPEEQR EFLAWTRNIK
ECCPGSAYSI AADCTPSASV GATAFPSVNT VDSNGDGVAS SVSVSVNSAI AIADHIGLHD
PPAAADDVFV SVGIPATSTT ESVAGTADGK GQGEGAAEGS ELHTRSESSV TQPVDAAAAA
GAGGTGAACE VNRVNTTPSA ETEAYGRFEH HAVSASAPEP QSPPRVGSAS RIVREGSMPG
TDVE
//
