ID D8LN43_ECTSI Unreviewed; 1147 AA.
AC D8LN43;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=DIS3-like exonuclease 1 {ECO:0000256|ARBA:ARBA00016366};
GN ORFNames=Esi_0043_0043 {ECO:0000313|EMBL:CBN74806.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN74806.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN74806.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000256|ARBA:ARBA00004229}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|RuleBase:RU003901}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN648630; CBN74806.1; -; Genomic_DNA.
DR AlphaFoldDB; D8LN43; -.
DR STRING; 2880.D8LN43; -.
DR EnsemblProtists; CBN74806; CBN74806; Esi_0043_0043.
DR eggNOG; KOG2102; Eukaryota.
DR InParanoid; D8LN43; -.
DR OrthoDB; 211091at2759; -.
DR Proteomes; UP000002630; Chromosome LG03.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR PANTHER; PTHR23355:SF30; DIS3-LIKE EXONUCLEASE 1; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 570..964
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 29..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 121259 MW; 2CB55726BA25A535 CRC64;
MGAMRIRETY LRGDRLLVSM KDTLLGEGGG EEGEGCSFQA TGGGEDSRKH NKRRCSYVCP
TADFLHCYLE LFDRPNFSAC FQRDGGSGAA AAPAAGTSNA AHPPAAGATG GGASGQERPP
RCCLLLLHSE LSKLTGATGA LSMKQERRLS QLARSLPGTM VFFDKFCPDL HGASAGATAG
ATDPGERSPS EALAVGGHAR MGGTGAAGGG GAGLPRVLGL REFLRGYVGG DAEEELARRG
DLLRRAHLSC KAATTSSSKA GGGGATGTAT TSSPLQKPHP SKTQLEALVA SGAASKGRLD
VFEHNPKEGV VVVGAGGGAA LDGWTDASGR AKVLVAGREG MNRSMHGDTV AVTLLPRRRW
RAPTDRKRLT HAAEEEEDIP LEEFQDAEGA GDGGEAPPGA MPTGFVVGVL EEGRRPYVVT
IPSEETTGQG GTATVAAVPM DPRVPKIRIK TRQLAQISGQ RLVVMVDGWD VGHVFPFGHY
VTSLGPVGEV SSEAAALLVE CEASFQPFSF NALASLPLVP NPPKESQKPR DALLPPATLA
ERERPEDGFG KAPRWQDSGW RVQESDVAGR RDLRKERAMS VDPPGCQDID DAMHVKRKPN
GKLEIGVHIA DVTRFVEADS PLDREARARA TTVYLVHRRI DMLPALLSSD LCSLHAGEDR
LSVSVVWEAE EDGDEDIRLC KGADGSPVCW FGRTVIHSKA SMTYDQAQML VEDGRIEKKK
GHEEPPSGQA GRDVREGLQP GLAHDLRLLT RFARTARAER VRNGAIDLSQ AGAELKFKID
PVTGTPLAVA GKEDSEIHHT IAELMILANS AVAEKIQGAF PSQALVRVHA SPDPSRLTAF
EGVAAKVGVN STSESSGKPN SSAGGLSQSL ATVEGGALRG QGEGGKSKAG LLKSLAVRAM
SEAEYVSTGT LSDHQAHGKG LEAQEESRFG HFGLGLSHYT HFTSPIRRYA DIVVHRLLLA
SLGVSVTQAS NATHHTTKPP PRLPSGDGFN APPAANRGDD DEGVLALPSS LAPSVMEMEE
AAVGMVEADA AAERRPRRAG AGDASFVINP DGTRTYSKAS GLAGVSSTRH FPIVVVYLAP
TPVPTPVPAA PDTFQFLPST LYQHQCQHQY QQHQTLFQFL PSTLHQHQCQ HQYQQRQGSA
SLRAAGK
//
