ID D8LQH7_ECTSI Unreviewed; 739 AA.
AC D8LQH7;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 08-NOV-2023, entry version 57.
DE SubName: Full=Arginine-N-methyltransferase {ECO:0000313|EMBL:CBN78741.1};
GN Name=SKB1 {ECO:0000313|EMBL:CBN78741.1};
GN ORFNames=Esi_0006_0115 {ECO:0000313|EMBL:CBN78741.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN78741.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN78741.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648818; CBN78741.1; -; Genomic_DNA.
DR AlphaFoldDB; D8LQH7; -.
DR STRING; 2880.D8LQH7; -.
DR EnsemblProtists; CBN78741; CBN78741; Esi_0006_0115.
DR eggNOG; KOG0822; Eukaryota.
DR InParanoid; D8LQH7; -.
DR OMA; WEFSHPI; -.
DR OrthoDB; 5489665at2759; -.
DR Proteomes; UP000002630; Chromosome LG04.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR035075; PRMT5.
DR InterPro; IPR035248; PRMT5_C.
DR InterPro; IPR035247; PRMT5_TIM.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10738; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR PANTHER; PTHR10738:SF0; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR Pfam; PF05185; PRMT5; 1.
DR Pfam; PF17286; PRMT5_C; 1.
DR Pfam; PF17285; PRMT5_TIM; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01015}.
FT DOMAIN 31..299
FT /note="PRMT5 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF17285"
FT DOMAIN 307..473
FT /note="PRMT5 arginine-N-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF05185"
FT DOMAIN 476..617
FT /note="PRMT5 oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF17286"
FT REGION 160..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 82450 MW; 1A1A9BB0D366F47A CRC64;
MAEKGKLIIG FETNCVPDLN ALLDDARKDH FDFVAIPLVH PRFKRDALGV SSRREDPLTR
SDFLLDSRQW SSLIVGKISE WLDMDSPCEE SAWASELAFK QEMAWATHLA LAAVIAPAPK
PGRCSNYARC INQVAQELTY LAVWLRIPLV HPESLDPELN GTKGSAINGK GGSGGEGEGG
DVGKVSTGGG TGAVEDPWET WNAIRVMCEH KSCLSVVLEM TADLPAQSIL DRWVGEPVKA
VIVSTKVFLT NKKGFPTLSR RHQDFATAMI KQKVQFVVKG RSHHASGYLP YLQYLEHLRT
RLPAPKEHEN FEAPYLDYLQ APLQPLMDNL ESQTYEAFEK DPVKYKQYER AIVKALELEK
KKEGIDTTVL MVVGAGRGPL VQAALNAGAT AGRPLKVYAV EKNANAVITL RNRAIMDKWT
NVTIVAKDMR EFAPEEKADI LVSELLGSWG DNELSPECLD GAQRFLKDGG VSIPQEYTSY
VAPMSSHKLW REVSNFEELK RLETAYVVKL HNFVQLAEEK ACFTFHHPSE EVGGEVHNKR
HVEVDFDVEQ ASTLHGFAGF FDSRLFADIH ISIVPSTFSE GMFSWFPLYI PLRTPVVLKP
GDKVSAHFWR CTSSNKVVVR VGPHLPRPLT NTQSQRSILL DRPLACGTRR TSRVRLASWC
GCRQCQRYVA SELFRFCLKQ RCCDFLGSQA VSRRPCLGMR PAVLPPFCGE ALDGVCVCTT
RHPHSIWGTN SSCCQVCRH
//
