ID D8LRB0_ECTSI Unreviewed; 1613 AA.
AC D8LRB0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN ORFNames=Esi_0064_0062 {ECO:0000313|EMBL:CBN75015.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBN75015.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBN75015.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648863; CBN75015.1; -; Genomic_DNA.
DR STRING; 2880.D8LRB0; -.
DR EnsemblProtists; CBN75015; CBN75015; Esi_0064_0062.
DR eggNOG; KOG1840; Eukaryota.
DR InParanoid; D8LRB0; -.
DR OrthoDB; 366694at2759; -.
DR Proteomes; UP000002630; Chromosome LG16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002151; Kinesin_light.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13374; TPR_10; 2.
DR Pfam; PF13424; TPR_12; 1.
DR PRINTS; PR00381; KINESINLIGHT.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 551..810
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1352..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1568..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1613 AA; 173141 MW; 95CE6291BD63613A CRC64;
MRSNSLPMSS GTDGRPWWEN SSSGSGVVEE EMEPEPYPPN LERGVKVRKR SMAGKSEIRR
LYVRGDTIEL VNPEKRMFRS QSKVFPLSEL TAVVAQGERS LSLSLGAKGL HLTLADRATK
EYLWEHLRKM REQAREQAKA SRITRAASID MIGSASQDFK RPKGGRKSVQ FQVPENEGLD
SDTTDSPLPE FLSNPDVRFE VTPGDRAALR AALEQLRDAL KRATISSESS FTISRSAPGL
MPTANAVALS GMRMSRMSAS SPSGGTVSGG VVTGGGGGGG GGGAVIGGGA DGGAGTGGGD
QGRLGKQYGS GLPSLLACLK GLKRAGTRLS ERHFFCYVGG FTELVSAAEK AWVAISKRSP
PDVAAVDRVK AAIIEGTHLA EDHGGGTGDV PHSGARLVVR MVRGLLESDG ERLKELSKRI
ATAARAPIVV GDVFQDEAAG ELQLRYMASL DGAPLDKAAR THEKLRTLSE LLAPFSCPET
QEPVSQLTIE DTSALLWRAH DMLYARMDAN VGRRGVFKSS VVPLLPPRRD LAPPPVLCPE
LPPHHLPRTA MQERVAAGLL GRVSPWDPPM VITGPPGAGK TVLSSAVARR SDVRRHFRDG
IFWLPAGKDA TERLPWLLEY LAVQLSLVLS SGQAGESKAN RMAALTGRGA KQDDEVEVEL
PWGTRGPREG EVAAFLAAHL ATRGLTCLLV VDDLWDRESL DQVRDLGFHV MVTANSKGLL
WTQQGAGLAA TLGSEVVAVD RMDDDECKLL LQRCSMIETV DWAALRDTEP VKSIIKLCRY
GPHALVMVGT TLQGQGRSFS WDATRDSLAR TVDSSRSLLQ NGASQDPDYV SLYSAGKVCT
LKLPDHIRNR YLHLAILPKH VPAPEQMLES LWDTESDEVF DEVLEKLRSH ALLQPVVILG
DQGRSGHVTS NTQMDYILHT AAGETVEHAA ARMSLYLGRL KVLKSGLGRK AGGKYLAMGR
CGLVSCWAEV EKRFGFTALE AYTDSIRAYR SSGKWASLTA PLPSGVRPWR WFRRDPRGHT
APSPLCAWPA WRGLQRSRAS PRSRRSCTVF GSRHPAVAAE TNVLAVFLVE HGRNREAEAC
YRNSMEIWER TLGPYSPELA SGLNNLAILL FVEDRPGEAA ATFQRSLDIR QRVLPPNSLE
TAQGLNNLAL LYTSQGQDST AAERLHREAL AIREARLGRN HPEVAQTCHN LALLLLKTGP
TTTHSPVGGG KPSSKTSADD KWQWEKVKAS KAPPSSETGL SSSLFKGLRL GGGGGNGAQQ
ANGTGPGGAG SGGESYRWRH TEAIKLLERA LAVHRETLGD DHPVTEESLQ ALAAAGGSST
PVTPSPSSRP SSISREVGLA VAAAAAGAGT AAAVSTPRSG PAGGGQPSPA ATTGSRPTSV
DPPPPSLECL NSSDHARETA REQQRQQQRE HEQRVKWEQD QAQKLARDHE LNKQRLREEK
RLKQERELVR QQNLEKQALA REEAELKAKA DKLLEDKGQA LFVQQQQRQL QNEQRERQRI
GSVESGSGDQ LVPGGIRGAS ASVSSAASLE RFYSADGAGI DAAAVAAASS SRAAVADTAA
PLLRARSAQG LGAASAGRRD EDDAVTRSFS YQAGADGAPE DGGADSPEGC RLA
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