ID   D8LV72_BLAHO            Unreviewed;       630 AA.
AC   D8LV72;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN   ORFNames=GSBLH_T00006028001 {ECO:0000313|EMBL:CBK19711.2};
OS   Blastocystis hominis.
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK19711.2};
RN   [1] {ECO:0000313|EMBL:CBK19711.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK19711.2};
RA   Wincker P.;
RT   "Sequencing and annotation of the Blastocystis hominis genome.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   EMBL; FN668638; CBK19711.2; -; Genomic_DNA.
DR   RefSeq; XP_012893759.1; XM_013038305.1.
DR   AlphaFoldDB; D8LV72; -.
DR   EnsemblProtists; CBK19711; CBK19711; GSBLH_T00006028001.
DR   GeneID; 24922153; -.
DR   InParanoid; D8LV72; -.
DR   OrthoDB; 5692201at2759; -.
DR   Proteomes; UP000008312; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   PANTHER; PTHR12411:SF962; CYSTEINE PROTEASE RD21C-RELATED; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008312};
KW   Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..630
FT                   /note="Peptidase C1A papain C-terminal domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018748583"
FT   DOMAIN          92..296
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   630 AA;  71555 MW;  889021E2ABE90F2F CRC64;
     MLAILFLFCL TAGLQTFAVS QISNFDQSRR QNFVENARKK EAAERLTGID LQYSFYSDFS
     ELRFRKYLMM NNRYPTPDPS EFPEKPPQIQ EIPESADWRS FFAPIVDIDP SIKCASSWAV
     AVTSLLYMKH KEQDPLWDQP FSVQQLLDCV VDRHALSPDT CDGASLESAL RYVYEKGLCL
     EKEYRPYSGT REKCPRTACN RYFLRNYRRV FPALSALLTA VHDQPVLATV GVNPAVLQFY
     VSESKNRPNF LRGAFHRYFI AGIVSSYNLA GSDRFVTLTI PSFHPLSRHL HFFVPANCLS
     AHSRGSSPVC EGDANSLAFY AYTAEIEPVP RFEHLFECES RGELVSRLDL RRSLAFGGNG
     AKPLDSAVEF GALRRNRGFH RDELTAVLRQ SAEALRNRAE FPWNSEPNPW REEFQSCRIA
     GISLIGLFPI DCPYSAEPIP AGEEEPRFIP SAGVCQLNGT AVNWVLELLE DCGDLEFLAL
     KDQGLESREI REILRFFLTR IQKFPRLKLI QLGGSFIGRE ESENIRGTIA ELAAMGVSVG
     GIAPFENETP DRAFFSELMN QPYQSLIVYT PISPFRFAAK ITLQNACTES PRECAYFSMD
     LALLFDRYPH YFLRTLDLTS LIFVGRMKSR
//