ID D8LVP0_BLAHO Unreviewed; 1684 AA.
AC D8LVP0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSBLH_T00000288001 {ECO:0000313|EMBL:CBK19879.2};
OS Blastocystis hominis.
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK19879.2};
RN [1] {ECO:0000313|EMBL:CBK19879.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK19879.2};
RA Wincker P.;
RT "Sequencing and annotation of the Blastocystis hominis genome.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FN668638; CBK19879.2; -; Genomic_DNA.
DR RefSeq; XP_012893927.1; XM_013038473.1.
DR EnsemblProtists; CBK19879; CBK19879; GSBLH_T00000288001.
DR GeneID; 24917603; -.
DR InParanoid; D8LVP0; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000008312; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008312}.
FT DOMAIN 1..175
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 212..423
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 841..1016
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1046..1239
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1684 AA; 192702 MW; 43E3BD6CEAFA42A8 CRC64;
MLVCAPTGAG KTNVALLTIL HEIKKIMEEL GVIRREEMII IYVAPMKALA QEIVAKFTNT
LGKLGLIVRE LTGDMQLTRQ EIAETQVIVT TPEKWDVITR KGGDNSLVEK VKLLILDEVH
LLASDRGNVI ESITARTLRQ IESTQKFIRL VGLSATLPNY MDVAEFLHVN LEPGKGLFYC
DDSFRPVPLT QRFIGITIQN KAKATEKQYE LAFDRVVEEL KIDKQAMVFV HSRRDTLVTA
LKILDYAQQK GKQGFFQTPI DHEEYSYYSG RVQRSHNAQL QKLFASGIGI HHAGMRRADR
SLVEEMFAKG VLRVICCTAT LAWGVNLPAH GVIIKGTQLY DASRGGWCDV DILDVIQIFG
RAGRPQFDTT GEGCIIGMHD SIDNFARLMV MKLPIESHFM KNLCDHMNAE IVAGTVTNIR
EAVIWIQYTY MYIRMLKSPK AYGVSNEERL RDPSLFLHCE NMVIDTATQL DNAHMIRYDM
ETGNLFPTDL GRVASHFYIA YSTIEIVNNT LLDTSTWETI LMIISQSQEF VSIKLRDEEI
AELKDMRSQC CRISTKAKLD DDFTKTFILL QAYISQWEPH EATLFSDFNF ISQNAGRITR
ALFEICIQRG WSNAAYKLLC LCRSIEKRIW FTDHPLSQVP IHRELLGRIV NRRLSLEDLR
DMKDDEISAY LDQRNIGKVV SNLVRMLPFY EVEGALQPVT STILRVSVSI KCAYNWTLKM
HGPIDQLWVW IENSQTHMIL YSEELQIQYK KRKEEQTLEF AIPVFPPLPE FYTLRVCSDH
WLGSDIEVYL PLRGLRMPHD SKRQTPLLDL DPLPVTALKN RGYQRLYSFS HFNAVQTQVF
FMSYHTDENL LICAPTGSGK TVVAELAVMR LLEAHKGEKA VYIGPLKSLV RQKLLDWKES
FENRLGHRVI ELTGDSAPEL GQIQRADIIV TTPEKWDGVS RQWEHRSYVQ KVGVIILDEI
HLLGADRGPI IEVIVSRLRF IAQKENRHIR VIGLSTALAN ATDLGDWLGI HGTGLYNFSH
SVRPVQLQVH ISGYPGKHYC PRMATMNKPC YTAIRQYSPH KPVLVFVASR RQTRLTAFGL
INYAAFDDPF QWLHMNPEEM RVIISTIRDE SLRETLPFGV GIHHAGLCAN DRMIVERLFS
QEKIQILCTT STLAWGVNLP AYLVIVKGTE YHDGKTCRWV DYPITDVLQM MGRAGRPQYD
SEGVACVMVH DIKKNYYKKF LYEPFPVESS LHLHLHDHIN AEIAAGNLKN VQDVIDYLSW
TFFYRRLLSN PSYYGLYSDK VEDIQTFLLD MVTSVLRTLE SAGCIKLKEN NAIESLKLGQ
ISSFYYVAYS TVHLFANDLF QIETIPELLT LISNATEYDP EPVRHNEEIH NEALSHNMYW
PVDENANFED PHIKTYLLLQ SFMLRLPLPV ADFVNDQSSV LDNSIRLINA LADIAGELKL
SNQLRLIFTT MPLLIQAIMP YDSEFLQLDG MDNSIMKRLK NEGYRKLKDF RNHSESELMD
VMMKCRLDSN LASKIIKSFF NLPELIVAFS ILDDKKQLDP ANLVLLVEKE YVVEVSLKLK
KVVPQRVFAP RFKKPKNYSY FVFVENAAGQ ILTWKRASVV KNTTVKLPIC LKSVGSQELT
IRVMCDSVVG IDESMDMNVK VTGSEEEAQQ FESSTRSFQE YKDDEMDADQ FEDEIFDEYL
ADGF
//
