ID D8LVQ2_BLAHO Unreviewed; 434 AA.
AC D8LVQ2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=UDP-glucose/GDP-mannose dehydrogenase C-terminal domain-containing protein {ECO:0000259|SMART:SM00984};
GN ORFNames=GSBLH_T00000298001 {ECO:0000313|EMBL:CBK19891.2};
OS Blastocystis hominis.
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK19891.2};
RN [1] {ECO:0000313|EMBL:CBK19891.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK19891.2};
RA Wincker P.;
RT "Sequencing and annotation of the Blastocystis hominis genome.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR EMBL; FN668638; CBK19891.2; -; Genomic_DNA.
DR RefSeq; XP_012893939.1; XM_013038485.1.
DR AlphaFoldDB; D8LVQ2; -.
DR EnsemblProtists; CBK19891; CBK19891; GSBLH_T00000298001.
DR GeneID; 24917613; -.
DR InParanoid; D8LVQ2; -.
DR OMA; IDPWFIV; -.
DR OrthoDB; 5399932at2759; -.
DR Proteomes; UP000008312; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR PANTHER; PTHR43491; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR PANTHER; PTHR43491:SF2; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008312}.
FT DOMAIN 319..422
FT /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00984"
SQ SEQUENCE 434 AA; 48125 MW; A881A9898598F118 CRC64;
MEDLVICVVG LGYVGIPMAV AFAEKGVRVI GFDISKPKVE AYINGYDPTQ EVGSERLLKA
LKGGLLSITS ELEDIRAANF YIVAVPTPVN EDRSPDVGPV RGASETIGKV LSKGDYVVFE
STVYPGLTEE LCIPIIEKLS GLKYKEEWKL GYSPERINPG DKVHTFRTIK KIVSGCDAES
LEKIASVYEM VVEPGVHRAT SIAVAEAAKV IENSQRDINI AFMNELAIIF DKMGIDTHDV
LEAAGTKWNF LHFFPGLVGG HCIGVDPYYL TYRAQNLGYT SRIIQNGRLL NDSMGEWIAT
KVVKLMVQLG LVVRGARVCV MGITFKENCC DARNSKVYDI IKELKEYEIE VVCCDPWAVK
DEVKRFYGVD VVDLSEVKDC DAVVMAVAHR EFASMSMKDL RALFKPSVAK KLVYDVKSVI
SREDVPEDMV LKRL
//
