ID D8LVZ7_BLAHO Unreviewed; 480 AA.
AC D8LVZ7;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) {ECO:0000256|ARBA:ARBA00013011};
DE EC=1.1.1.44 {ECO:0000256|ARBA:ARBA00013011};
GN ORFNames=GSBLH_T00000382001 {ECO:0000313|EMBL:CBK19986.2},
GN GSBLH_T00003921001 {ECO:0000313|EMBL:CBK24154.2};
OS Blastocystis hominis.
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK19986.2};
RN [1] {ECO:0000313|EMBL:CBK19986.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK19986.2};
RA Wincker P.;
RT "Sequencing and annotation of the Blastocystis hominis genome.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the oxidative decarboxylation of 6-phosphogluconate
CC to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP
CC to NADPH. {ECO:0000256|ARBA:ARBA00002526}.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 3/3. {ECO:0000256|ARBA:ARBA00004874}.
CC -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00008419}.
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DR EMBL; FN668638; CBK19986.2; -; Genomic_DNA.
DR EMBL; FN668683; CBK24154.2; -; Genomic_DNA.
DR RefSeq; XP_012894034.1; XM_013038580.1.
DR RefSeq; XP_012898202.1; XM_013042748.1.
DR AlphaFoldDB; D8LVZ7; -.
DR EnsemblProtists; CBK19986; CBK19986; GSBLH_T00000382001.
DR EnsemblProtists; CBK24154; CBK24154; GSBLH_T00003921001.
DR GeneID; 24917694; -.
DR GeneID; 24920974; -.
DR InParanoid; D8LVZ7; -.
DR UniPathway; UPA00115; UER00410.
DR Proteomes; UP000008312; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006114; 6PGDH_C.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006183; Pgluconate_DH.
DR PANTHER; PTHR11811; 6-PHOSPHOGLUCONATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11811:SF25; 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF00393; 6PGD; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PRINTS; PR00076; 6PGDHDRGNASE.
DR SMART; SM01350; 6PGD; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Gluconate utilization {ECO:0000256|ARBA:ARBA00023064};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Pentose shunt {ECO:0000256|ARBA:ARBA00023126};
KW Reference proteome {ECO:0000313|Proteomes:UP000008312};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 414..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..476
FT /note="6-phosphogluconate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01350"
SQ SEQUENCE 480 AA; 52559 MW; C9D79670630778F4 CRC64;
MSSDIGIYGL STRAINLALN FAAKGLSVSI GHRSSDLIKE CTHQAEKKDL DEKITGKKDV
NGFCDSLSSP KKVILMSKPG TSAEKNYSKI LAALEEGDLL IDATSEGYEI NLRREKEAAE
KGVRFLTMEI LGTTKELQKG CGFLLSGERE AYDLVEGPLK KAATEVEYEP CVAYIGNSVS
AGYAGMALSS LGLGMEQLVA EAYHMLHEAG FTNEEVSKSI NGWNKDSLAS PFLENLLHIL
KKKDQDVEGC EKGEGSLLDK VLDCPLPRPD HSTLLREGFE HHAAIGALTA AVQEIAVSAK
REERSKAATL WNGPEFDWQK LDHVQLIEDL RNTFVCGQLV LATQTFALLR RASEDFSWAM
KLEEVGRVVA GAASFRSGLL VVLKESVENG DLSLLQNEAV SEILQKKQAS WRRVAALAVI
GGVSAPVATA SLAYYDTMRR DKLPQNVVVA MRDFLEASSF ERTDCARGMT YHCEWTKETN
//