ID   D8LX60_BLAHO            Unreviewed;       854 AA.
AC   D8LX60;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=GSBLH_T00001108001 {ECO:0000313|EMBL:CBK20855.2};
OS   Blastocystis hominis.
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK20855.2};
RN   [1] {ECO:0000313|EMBL:CBK20855.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK20855.2};
RA   Wincker P.;
RT   "Sequencing and annotation of the Blastocystis hominis genome.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FN668639; CBK20855.2; -; Genomic_DNA.
DR   RefSeq; XP_012894903.1; XM_013039449.1.
DR   AlphaFoldDB; D8LX60; -.
DR   EnsemblProtists; CBK20855; CBK20855; GSBLH_T00001108001.
DR   GeneID; 24918387; -.
DR   InParanoid; D8LX60; -.
DR   OMA; DIVCHIC; -.
DR   OrthoDB; 3141960at2759; -.
DR   Proteomes; UP000008312; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR31511:SF12; DNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR31511; PROTEIN CBG23764; 1.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008312}.
FT   DOMAIN          244..589
FT                   /note="DNA-directed DNA polymerase family B
FT                   mitochondria/virus"
FT                   /evidence="ECO:0000259|Pfam:PF03175"
SQ   SEQUENCE   854 AA;  99731 MW;  EA011D7D39ED5359 CRC64;
     MDYLVQLQGS VKTYLFDELP LENSPSIEKD FRATTVCPFC RKKLEDDKVR HHAHVAAGQY
     ICTCCTKCNL QLSFNKKNYR LPVYFHNGSH YDFTFIMKLI ATMPGGNLEV IPTTEDKEMQ
     IEYNGIQFKD SLKLISSPLR SIVAQTLGGN LDLYVHTKQQ LRKYCESRGK QWDDEYIDLL
     TRKEPMFYSL IKSYDTLNNT TIPSREQCID DMKGEMMPQD EYDHMVKLWK TFDIKTWGEY
     YELYNVLDVT LMADAFEHFR VTTLNAFGVD PMHYITAPQM AYSLFLKVTM EGDHSESNLM
     TLARKWAQYI MRINANEGLA EKQLVKVFLN RMGEFYESKG IRLMETNDID DFMRLLKNLR
     GGITQIVKRH AKVDIDNKEQ ATSSQGIYYL DANNLYGGAM HRMMPYELVG VPERREVMER
     INRDPNGWVQ SLKTFGKYGF FIECDIEAPV ELHDKFNDLP FFPVQKAGMY SDGIKKYAEK
     NDIVDKVKEV NTPKLICDLV PRRKYLVHYS LLQLGIQQGY RVTHIHHLIR FKQAPFIFEY
     VNMLSEKRAK SKTTVEKNLY KLLANSTYGK FVETGLKRMK VKFANTWNER EAIIQKHGYD
     MIAGTTMYSE NLIGIKLNTP VRRVEKPFFI GFAILDMSKH IIYDFYYNVL KNTFDTVELL
     GQDTDSLIVQ LHDRANIVHK MCDMYKSFDF SELDNTSYFY GELVKYYDHE VNKSKFPSLD
     SFLNFNKKLP GPIFKDEHNG HRITEFVGLR PKMYCLVDEK HVIHNAAKGV PRNVVIDGER
     MSVKNIDLYK RVLEAEKKED AVIEGSFKRI NNQAFDISTK EQTKTLMTCT DNKRWILDDN
     VHTLAFGHYR LKDM
//