ID   D8M2U3_BLAHO            Unreviewed;       698 AA.
AC   D8M2U3;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=GSBLH_T00002764001 {ECO:0000313|EMBL:CBK22666.2};
OS   Blastocystis hominis.
OC   Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC   Blastocystis.
OX   NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK22666.2};
RN   [1] {ECO:0000313|EMBL:CBK22666.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK22666.2};
RA   Wincker P.;
RT   "Sequencing and annotation of the Blastocystis hominis genome.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; FN668650; CBK22666.2; -; Genomic_DNA.
DR   RefSeq; XP_012896714.1; XM_013041260.1.
DR   AlphaFoldDB; D8M2U3; -.
DR   EnsemblProtists; CBK22666; CBK22666; GSBLH_T00002764001.
DR   GeneID; 24919904; -.
DR   InParanoid; D8M2U3; -.
DR   OMA; MKVYPLY; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000008312; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008312}.
FT   DOMAIN          49..216
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          241..414
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   698 AA;  80046 MW;  4399B04B1E25A7CA CRC64;
     MNSKYTKATD LIFKSKQNPL TGKPFSDNYY KILEERKKLP VFEFLDTLEQ AVDSNQVIIV
     EGETGSGKTT QIPQALTLHY LSKNPDSNKM ICCTQPRRVA ALTVAKRVSE EMDVEFGEEV
     GYTIRFEDYT SERTKLKYMT DGMLEREAMN DPLLSRYSII LLDEAHERTL ATDIMMGLLK
     ELLPKRPDLK LIVMSATLDA GRFQKYFNNA PLFSVPGRVY PVDIYFTPKP EREYVEAAIR
     TVIQIHLLED PGDILLFLTG EQEIMDTCDR LEEEQASFPK DKQNLIILPL FSSLPPQQQQ
     LVFEPTPEGS RKVVIATNIA ETSITINGVV YVIDPGFSKQ KVYNPRIRVE SLLVTPISKA
     SARQRAGRAG RTRPGKCFRL YTEESFNTQL LEQSYPEIMR SDISSVILTM KKLGIENLVR
     FDFMDPPAPE TMMRALENLN YLGALDDEGE LTELGNEMAE LPLDPQLSKA LLSSKEYGCV
     PEMLTITAML SIPPPFLRPR ESARFADEAK SQFVHADSDH ITLLNLYNAF VEVPTKARSK
     WCYDNYINYR SISSALNVRH QLEGILRRLH YDVTNGNHFE STYYFTNIKK SIFAGFFMQV
     AHRERTGHYL TIKDNQVVKL YPSSVMKNKP DWVMFHEFVL TTANYMRTVT AVDGEWLMDI
     APQYYDLDSF PDCSAKNDII AIERRKKLIR ENSKRRKH
//