ID D8M3X3_BLAHO Unreviewed; 677 AA.
AC D8M3X3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=N-acetylglucosaminylphosphatidylinositol deacetylase {ECO:0000256|ARBA:ARBA00012176};
DE EC=3.5.1.89 {ECO:0000256|ARBA:ARBA00012176};
GN ORFNames=GSBLH_T00006477001 {ECO:0000313|EMBL:CBK22596.2};
OS Blastocystis hominis.
OC Eukaryota; Sar; Stramenopiles; Bigyra; Opalozoa; Opalinata; Blastocystidae;
OC Blastocystis.
OX NCBI_TaxID=12968 {ECO:0000313|EMBL:CBK22596.2};
RN [1] {ECO:0000313|EMBL:CBK22596.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Singapore isolate B {ECO:0000313|EMBL:CBK22596.2};
RA Wincker P.;
RT "Sequencing and annotation of the Blastocystis hominis genome.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PIGL family.
CC {ECO:0000256|ARBA:ARBA00006066}.
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DR EMBL; FN668650; CBK22596.2; -; Genomic_DNA.
DR RefSeq; XP_012896644.1; XM_013041190.1.
DR AlphaFoldDB; D8M3X3; -.
DR EnsemblProtists; CBK22596; CBK22596; GSBLH_T00006477001.
DR GeneID; 24922601; -.
DR InParanoid; D8M3X3; -.
DR OrthoDB; 103492at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008312; Unassembled WGS sequence.
DR GO; GO:0000225; F:N-acetylglucosaminylphosphatidylinositol deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10320; LmbE-like; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR003737; GlcNAc_PI_deacetylase-related.
DR InterPro; IPR024078; LmbE-like_dom_sf.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR12993:SF11; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE; 1.
DR PANTHER; PTHR12993; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED; 1.
DR Pfam; PF02585; PIG-L; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF102588; LmbE-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008312};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..677
FT /note="N-acetylglucosaminylphosphatidylinositol
FT deacetylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003117714"
FT DOMAIN 277..488
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT COILED 637..671
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 677 AA; 79132 MW; DCE80590C98C3E7D CRC64;
MNRVFGILAI LAVWLSGALV RVKKPIVPDH NCLFVLAHPD DESMFMIPTI LALNKSTLYF
LYYTNGDFEG LGDIREKELL SALTFLSVDP THIQIVHDHS IQDSPTLTWN ETKTVQILQS
AVEKWNVMEI FTFDAFGVSG HVNHISAHSA VASYCSNNNI SVRYLKSANL LTKYLGPFQM
SSAYTFRVWS PLMSWRAMSL HRTQFLWYRR LFVLFSCYSY VNVWNELCLS EKVFEVISLS
SSFFDRFDFI SLCKIGIQSR KRLGKPENIL PFLRYPCKPN RFIPHFWELV LKLYSTEVLY
PISKDNYCFE WYNPFLNKNE GEISRDVCRT FPHHLLFRHK ENESVLRKVS DNYFGLGYCQ
GMNYVAGTIM IALVDPELNG YYSDNDTDEL QYRIRNLDTE DIRNQMYEIM SLLIDRLQMV
RLWGYGFPDL PLFVFVLRNR YAPDLRDHLE SLGFDLSIIV TRWFIPLFSN NMPFSLVFRI
WDYLFIVGIS GLFRVTMALL LQYKKIILQS DLVQISSFIH DVGLSHLQKE KEVQAFFKTM
ISLHDVGEES RNDLQIDRVS MSEECKVKHE QLSSDIRVLL ERIKNIHDEE VLLRNDLRNN
LLDETRFTDE LGDLNQKKAK AERSYVRLVK LGQQANLSEY VNQISVLEEC IQQVEADLAS
LKKRISERIE SGNERRE
//
