ID D8MNZ4_ERWBE Unreviewed; 589 AA.
AC D8MNZ4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Multidrug resistance-like ATP-binding protein {ECO:0000313|EMBL:CAX58551.1};
GN Name=mdlA {ECO:0000313|EMBL:CAX58551.1};
GN OrderedLocusNames=EbC_10200 {ECO:0000313|EMBL:CAX58551.1};
OS Erwinia billingiae (strain Eb661).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=634500 {ECO:0000313|Proteomes:UP000008793};
RN [1] {ECO:0000313|EMBL:CAX58551.1, ECO:0000313|Proteomes:UP000008793}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Eb661 {ECO:0000313|EMBL:CAX58551.1,
RC ECO:0000313|Proteomes:UP000008793};
RX PubMed=20565991; DOI=10.1186/1471-2164-11-393;
RA Kube M., Migdoll A.M., Gehring I., Heitmann K., Mayer Y., Kuhl H.,
RA Knaust F., Geider K., Reinhardt R.;
RT "Genome comparison of the epiphytic bacteria Erwinia billingiae and E.
RT tasmaniensis with the pear pathogen E. pyrifoliae.";
RL BMC Genomics 11:393-393(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug exporter-2
CC (TC 3.A.1.117) family. {ECO:0000256|ARBA:ARBA00006526}.
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DR EMBL; FP236843; CAX58551.1; -; Genomic_DNA.
DR RefSeq; WP_013201051.1; NC_014306.1.
DR AlphaFoldDB; D8MNZ4; -.
DR STRING; 634500.EbC_10200; -.
DR KEGG; ebi:EbC_10200; -.
DR eggNOG; COG1132; Bacteria.
DR HOGENOM; CLU_000604_84_3_6; -.
DR Proteomes; UP000008793; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18541; ABC_6TM_TmrB_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF300; MULTIDRUG RESISTANCE-LIKE ATP-BINDING PROTEIN MDLA; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CAX58551.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008793};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..303
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 337..570
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 589 AA; 66026 MW; A89412335208523D CRC64;
MRLFSQLSWY FIREWRRYLG AVALLIVIAI LQLLPPKVVG MVVDGVSHQQ MSTSQLMMWI
GVMLITAVVV YLLRYVWRVL LFGASYQLAV ELRQDFYRQL SRQHPEFYLR HRTGDLIARA
TNDVDRVVFA AGEGVLTLVD SLVMGLVVLF VMSTQISWQL TLLALLPMPI MAIVIKRYGD
QLHNRFKLAQ AAFSSLNDQT QESLTSIRMI KAFGLEDHQS GQFADIAKDT GRKNLRVARV
DARFDPTIYI AIGMSNLLAI GGGSWLVWHD QMTLGQLTSF VMYLGLMIWP MLALAWMFNI
VERGSAAWSR IRSLLSEAPA VEDGSKTLPE ERGSLQIAIR EFCYPGAQNP SLRHVNVHLK
PGQMLGLCGP TGSGKSTLLS LIQRHFDISQ GDIRFHGIPL PQLRLDSWRG RLAVVSQTPF
LFSDTIANNI ALGRPTAKPA DIEQAARLAN VHDDILRLPK GYDTEVGERG VMLSGGQKQR
ISIARALLLD AEILILDDAL SAVDGRTEHQ ILHNLRRWGQ GRTVIISAHR LSALTEASEI
LVMQKGAVTQ RGEHEQLAAE SGWYQDMYRY QQLEAALDEE EIEKGVPHG
//
