ID D8MPV9_ERWBE Unreviewed; 226 AA.
AC D8MPV9;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN OrderedLocusNames=EbC_13350 {ECO:0000313|EMBL:CAX58866.1};
OS Erwinia billingiae (strain Eb661).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=634500 {ECO:0000313|Proteomes:UP000008793};
RN [1] {ECO:0000313|EMBL:CAX58866.1, ECO:0000313|Proteomes:UP000008793}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Eb661 {ECO:0000313|EMBL:CAX58866.1,
RC ECO:0000313|Proteomes:UP000008793};
RX PubMed=20565991; DOI=10.1186/1471-2164-11-393;
RA Kube M., Migdoll A.M., Gehring I., Heitmann K., Mayer Y., Kuhl H.,
RA Knaust F., Geider K., Reinhardt R.;
RT "Genome comparison of the epiphytic bacteria Erwinia billingiae and E.
RT tasmaniensis with the pear pathogen E. pyrifoliae.";
RL BMC Genomics 11:393-393(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; FP236843; CAX58866.1; -; Genomic_DNA.
DR RefSeq; WP_013201360.1; NC_014306.1.
DR AlphaFoldDB; D8MPV9; -.
DR STRING; 634500.EbC_13350; -.
DR KEGG; ebi:EbC_13350; -.
DR eggNOG; COG0693; Bacteria.
DR HOGENOM; CLU_070319_2_0_6; -.
DR Proteomes; UP000008793; Chromosome.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008793};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 25..222
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
FT REGION 49..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 24400 MW; B152B21D215524C8 CRC64;
MKLLMVLTSH DRLGETGKKT GFWLEEFAAS YYVFRDAGVN VVLASPAGGQ PPLDPVSDEP
DAQTTDTDRF RGDLPAQQAL AHTQKLETID STQFDAVFYP GGHGPLWDLA EDRVSIDLIE
NFFANGKPVG AVCHAPGVLR HVKKPDGTPL VAGKRVTGFS NTEEEAVGLT DVVPFLVEDV
LKSLGAEYEK TDNWGVYTLT DGHLVTGQNP ASSAAAAEEL LKLLHR
//
