ID   D8PMN8_SCHCM            Unreviewed;      1118 AA.
AC   D8PMN8;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Antiviral helicase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SCHCODRAFT_64062 {ECO:0000313|EMBL:EFJ03523.1};
OS   Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN   [1] {ECO:0000313|EMBL:EFJ03523.1, ECO:0000313|Proteomes:UP000007431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX   PubMed=20622885; DOI=10.1038/nbt.1643;
RA   Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA   de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA   Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA   Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA   Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA   Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA   Woesten H.A.B.;
RT   "Genome sequence of the model mushroom Schizophyllum commune.";
RL   Nat. Biotechnol. 28:957-963(2010).
CC   -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010140}.
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DR   EMBL; GL377302; EFJ03523.1; -; Genomic_DNA.
DR   RefSeq; XP_003038425.1; XM_003038379.1.
DR   AlphaFoldDB; D8PMN8; -.
DR   STRING; 578458.D8PMN8; -.
DR   GeneID; 9589678; -.
DR   KEGG; scm:SCHCO_02490005; -.
DR   VEuPathDB; FungiDB:SCHCODRAFT_02490005; -.
DR   eggNOG; KOG0947; Eukaryota.
DR   HOGENOM; CLU_002902_1_4_1; -.
DR   InParanoid; D8PMN8; -.
DR   OMA; CGSDITR; -.
DR   OrthoDB; 1352at2759; -.
DR   Proteomes; UP000007431; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 1.
DR   Gene3D; 1.20.1500.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   InterPro; IPR040801; Ski2_N.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   Pfam; PF17911; Ski2_N; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          173..331
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          453..646
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          377..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1118 AA;  124008 MW;  4F02FA35F1BF3DFA CRC64;
     MTRAPASSAN FVRGKSGHVP FWPGGLEDAV ISRGTGDISE EEKKQLRTVA PGLSRGLRLP
     GDPEEDDVLQ ELEGIYASED AENGGEAEAS NGHVEAEAPV AGSTEIDELL PTTRANLNPI
     KASQRKRPRT KIQKRDWAHV IDVNKPLNNF HELVPEMAHK YPFELDTFQK QAVYHLEMGD
     SVFVAAHTSA GKTVVAEYAI ALAEKHMTRA IYTSPIKALS NQKYRDFKQT FSSQNVGILT
     GDVQINPEAN CLIMTTEILR SMLYKGADLI RDVEFVIFDE VHYVNDAERG VVWEEVIIML
     PDHVSIILLS ATVPNTKEFA DWVGRTKKKD IYVISTAQRP VPLEHYLYAG RDLFKIVDAK
     RNFLALGYKE AGEALRRKQD KEREAAGLPP VQRVGARGGA QGQRGGRGGP PARGGRGAAP
     PARGGRGGST GGRVVHMDKN LYVHLLGNLR KRNLLPVVVF TLSKKRCEEN ASTLTNQDLC
     TSVEKSEVHV AIEKALSRLK APDRKLPQIS RMRDLLSRGI GVHHGGLLPI VKELVEILFA
     RGLVKMLFAT ETFAMGVNMP AKSVVFSGIR KHDGRSFRDI LPGEYTQMAG RAGRRGLDPT
     GTVIIVANDS LPEQTALHTM MLGTPGKLIS QFRLTYNMIL NLLRVEALRV EEMIKRSFSE
     NASQRLLPEQ QKRVIEGEKT LAGLEKLACD ICVPSIESYY DDMNDVVNMN QKLLSMAVSH
     PQGARLLSAG RVVVLNDGHF KKNTIAALLR QAPVQASDDG VLSKVKTYYV LALVDQATKS
     GDFADINPDA IPPTWPPAAN SLAYDDPVYE LSAVPLTSIS LVEVDAIVDR HLISRMRDGI
     GQLGALVEEW SSAPEIPEID WSRMRALEFQ EILRERTRLV ERSRDSVCLH CPDFGRHYTT
     IHAEKVLRAN IANLKLAISD QNLELIPDYE QRIEVLKDLK FIDENCTVSL KGRVACEINS
     ANELVLTELI LENTLANYDP EEVVALLSCF VFQEKTDAEP AIPPKLKEGM EAIMAISDRV
     GAVQDYHKVA AEDFRSNLKF GLVEVVYEWA KGMPFEQITA LTDVAEGTIV RVITRLDETC
     REVRDAARVI GDAELFKKME ESQMKIKRDI VFAASLYF
//