ID D8PW05_SCHCM Unreviewed; 818 AA.
AC D8PW05;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Mitochondrial escape protein 2 {ECO:0000256|ARBA:ARBA00020222, ECO:0000256|RuleBase:RU367108};
GN ORFNames=SCHCODRAFT_81250 {ECO:0000313|EMBL:EFJ00128.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFJ00128.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC controlling the mtDNA escape. Involved in the regulation of mtDNA
CC nucleotide structure and number. May have a dispensable role in early
CC maturation of pre-rRNA. {ECO:0000256|ARBA:ARBA00025276,
CC ECO:0000256|RuleBase:RU367108}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434,
CC ECO:0000256|RuleBase:RU367108}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367108}.
CC -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000256|ARBA:ARBA00010320,
CC ECO:0000256|RuleBase:RU367108}.
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DR EMBL; GL377303; EFJ00128.1; -; Genomic_DNA.
DR RefSeq; XP_003035030.1; XM_003034984.1.
DR AlphaFoldDB; D8PW05; -.
DR STRING; 578458.D8PW05; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02607113; -.
DR eggNOG; ENOG502QS0P; Eukaryota.
DR HOGENOM; CLU_007861_1_0_1; -.
DR InParanoid; D8PW05; -.
DR OMA; WTPEQAW; -.
DR OrthoDB; 1384689at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR CDD; cd12433; RRM_Yme2p_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR018850; Mt_escape_2_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR039627; Yme2_C.
DR InterPro; IPR034260; Yme2_RRM.
DR PANTHER; PTHR32198; MITOCHONDRIAL ESCAPE PROTEIN 2; 1.
DR PANTHER; PTHR32198:SF2; MITOCHONDRIAL ESCAPE PROTEIN 2; 1.
DR Pfam; PF10443; RNA12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367108};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU367108};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW ECO:0000256|RuleBase:RU367108};
KW mRNA processing {ECO:0000256|RuleBase:RU367108};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176,
KW ECO:0000256|RuleBase:RU367108};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367108};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367108}.
FT TRANSMEM 243..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367108"
FT DOMAIN 147..225
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT COILED 786..813
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 818 AA; 92498 MW; 384057A231FB13C4 CRC64;
MLSRPSCSRM LVRRPVRAYA TASGTNEAWL FVDSLFPVRV GKLDPRHLIA RLREEHILNN
VRTTLSTVKD HDFEILSVVP YQKDGGAFIK FKYAGDEAAL PTIEQALKDS TRKSGGLQTW
IGLRRADVWL VKAKQPWLED MDRWASMSLR VEFLGGELPE EQVFELFRPY GRIEDIEAPK
VAGKNPAIVV EYRRYRPATI ARNVLNGYEV TLPSGAKVRV RPTYQPVMHA YAMRDWLSKH
PRIVLPVVIF LLGSLTYAIF DPIRSLMVEA KLLNWFDYKE YRLWQWFREN ALDRLPLTFE
SKIAAAPAED AWKERMEAFT AIRAYLNDFP STVAFIHGPQ GSGKTRMARA VLEPLDRPTL
EIDCRELVKS TSDAQMIGTL AKQTGYWPIF TFLNSMSNLI DLASVGMIGQ KAGFGSSTPD
QLRDILSTVT VSLKRANESH RNEMLKEAKR QEARQARTKG FSALWSRVTG LVGGEHEKPA
QEKSNHELKD EMARKVKGTQ DAEALQSLPT VVIRNYAGSG SNKEELLEVL AQWGTSLVEN
KIAHVLILSD NRENSKRLAK ALPTKPLYTV ALSDADPNTS LSYVKQKLQD ADVDSSFTSE
QIGLIQRLGG RASDLESLVH KVRNGQTVED AVEDIVSRGV AELRKNAFGD DADDAKNLPW
SREQAWHVLK QLAKQEEIPY QDLLLNFPFK GDENALRAME QAELITVGTN NGRPSAVRPG
KPVYKWVFER LYKDSIFEAM MDTAYNKKII DASETIVKDC EDELLKLKEI GLENGWLGRT
PSSERANYLY DKMMKAQRKI VQLERKNDEL KKVLAKGG
//
