ID D8Q073_SCHCM Unreviewed; 2351 AA.
AC D8Q073;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN ORFNames=SCHCODRAFT_75391 {ECO:0000313|EMBL:EFI99561.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI99561.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
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DR EMBL; GL377304; EFI99561.1; -; Genomic_DNA.
DR RefSeq; XP_003034464.1; XM_003034418.1.
DR STRING; 578458.D8Q073; -.
DR GeneID; 9586456; -.
DR KEGG; scm:SCHCO_01293303; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_01293303; -.
DR eggNOG; KOG1795; Eukaryota.
DR HOGENOM; CLU_000380_3_0_1; -.
DR InParanoid; D8Q073; -.
DR OMA; ANKWNTS; -.
DR OrthoDB; 246127at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2119..2250
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2351 AA; 271778 MW; E387F77383B87904 CRC64;
MSIPPPPPGF MAPPPGMPGA NNAGASGSRM PPEALAQKSL KWVQMQRKRY GEKRRGGYVD
MGKQDLPPEH VRKIIKDHGD MSNRKFRNDK RVHLGALKYV PHAVMKLLEN LPFPWEQVRE
VPVLYHITGA ITFVNEIPRV IEPVYHAQWS TMWLAMRREK RDRRHFKRMR FPPFDDEEPP
LDYGDNVLDV EPLEAIQLEL DEEEDAAIID WFYDPKPLID TPSVNGPSYK YWSLSLPVMA
NLYRLGRTLL SDQADNNAQY LFDKKSFFTA KALNMAIPGG PKFEPLYRDM DTFDEDWNEF
NDINKVIIRQ QIRTEYRVAF PHLYNSLPRS VHISPYHAPK NVYIRTDDPD LPTFYFDPLI
NPISLRGLTP KNMPLIAHED AVIGPNDDDD FEIPDEVEPF LEDKPLENDL SSDAIAIWWA
PEPYCRRSGH MRRAQDIPLI KNWYMEHCPP NQPVKVRVSY QKLLKCYVLN ELHTRPEKAM
TKKNLFRQLK ATKFFQTTRL DWVEAGLQVC RQGYNMLNLL IHRKNLNYLH LDYNLNLKPV
KTLTTKERKK SRFGNAFHLC REILRLTKLV VDANVQFRLG NVDAFQLADA LQYIFAHIGA
LTGMYRYKYK LMRQVRMTKD LKHLIYYRFN TGPVGKGPGV GFWAPGWRVW LFFMRGIVPL
LERWLGNLLA RQFEGRNSKG IAKTVTKQRV ESHYDLELRA AVMHDILDMM PESIKQNKSK
TILQHLSEAW RCWKANIPWK VPGMPTAIEN IILRYIKSKA DWWCSVAHYN RERIRRGATV
DKAVVKKNLG RLTRLYLKAE QERQHGYLKD GPYISAEEAV AIYTATVHWL ESRKFAPIPF
PPLSYKHDTK LLVLALEKLK EAYSVKGRLN QSQREELALI EQAYDNPHEC LSRIKRLLLT
QRAFKEAGIE FFDTYDKLIP CYDIEPVEKI TDAYLDQFLF FEADKRGLFP AWIKPADTEP
PPLLVYKWCQ GINNLTDIWE TSEGECNVMM ETVLSKVYEK IDLTLLNRLL RLILDHNLAD
YITAKNNVVL TYKDMAHTNA YGLIRGLQFS AFVFQYYGLV LDLLILGLQR ASEMAGPPQM
PNNFLQYRDS ATETRHPIRL YSRYVDRLHI LFRFTADEAR DLIQRYLSAN PDPTNNNVIG
YNNKRCWPRD CRMRLVKHDV NLGRAVFWNV KQSLPRSLTT IEWEDTFVSV YSQNNPQLLF
SMCGFEVRIL PKIRTISGEQ FSLKDAVWNL TNEQTKERTA QAFLRVSDEG VQQFNNRIRQ
VLMSSGSTTF SKIVNKWNTA LIGLMTYYRE AVIHTTELLD ALVKAENKIQ TRVKIGLNSK
MPSRFPPVVF YTPKELGGLG MLSMGHVLIP QSDLRWSKQT DVAVTHFRAG MSHEEDQLIP
NLYRYLQPWE AEFLDSARVW SEYSMKRKEA SAQNRRLTLE DLEDSWDRGI PRINTLFQKD
RHTLAYDRGW RVRTDWKQYQ LLKHNPFWWT SQRHDGKLWQ LNNYRVDVIS ALGGVESILE
HTLFKGTYFP TWEGLFWEKA SGFEESMRYK KLTNAQRSGL NQIPNRRFTL WWSPTINRAN
VYVGFQVQLD LTGIFMHGKI PTLKISLIQI FRAHLWQKIH ESVVMDLCQV FDQELEPLQI
ETVQKETIHP RKSYKMNSSC ADILLFSAYK WNIARPSLVT DQKDVLDGTT SNKFWIDVQL
RWGDFDTHDI ERYTRAKFLD YVSDSMSIYP SPTGVMIGMD LAYNLWSAYG NWFPGLKPLI
QQAMAKIMRA NPALHVLRDR IRKGLQLYSS EPTEPYLNSQ NYAELFSNQI IWFVDDTNVY
RVTIHKTFEG NLTTKPINGA IFIFNPRSGQ LFLKIIHTSV WAGQKRLGQL AKWKTAEEVA
ALVRSLPVEE QPKQVIVTRK GMLDPLEVHL LDFPNIVIKG SELQLPFQAC MKMEKFGDLI
LRATQPQMVL FSLYDDWLKS ISSYTAFSRL ILLLRGLHVN NEKAKIILHP DKNTITEPHF
VWPSLSDEEW IKVEVAMKEL ILADFGKRNS VNIASLTASE VRDIILGQEI AAPSVQRQQM
AELEKSSQAQ GQITAVQTQT TNVHGDAIQT VTTTNYEQTV FSSKSDWRVR AISATHLPLR
LQHIYVSNDD VKDDAASYTY VLPKNILRAF VTAADLRTQV AAYLYGVSPP DNKQVKEIKA
VAWVPQRGSN NSVELPNRLP KDDFLLKDLE LLGWIKTQAL EIPHLSPTDV TTQAQIMAEH
PEMGSSSICL TVSFTPGSIS LSAHSLTVAG FEWGRKNQDR SANPPGFNPN MSERVQLLLS
DRILGMTLVP EGRVWNYGIG LTQLWSQNVP YSMTLDTPLL FWAEEHRPAA FLTFASLEQG
EDSADVENSF A
//
