ID D8Q0F5_SCHCM Unreviewed; 677 AA.
AC D8Q0F5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
DE Flags: Fragment;
GN ORFNames=SCHCODRAFT_107898 {ECO:0000313|EMBL:EFI98348.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI98348.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|RuleBase:RU362003}.
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DR EMBL; GL377305; EFI98348.1; -; Genomic_DNA.
DR RefSeq; XP_003033251.1; XM_003033205.1.
DR AlphaFoldDB; D8Q0F5; -.
DR STRING; 578458.D8Q0F5; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02618306; -.
DR eggNOG; KOG0497; Eukaryota.
DR HOGENOM; CLU_009074_2_1_1; -.
DR InParanoid; D8Q0F5; -.
DR OMA; CWARQTI; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 82..347
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 499..657
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT NON_TER 677
FT /evidence="ECO:0000313|EMBL:EFI98348.1"
SQ SEQUENCE 677 AA; 77614 MW; 18A93A62122D38C3 CRC64;
MYNRIDAPVS GEKPFTDYNR WRLLVNDGGR HTWHYLETEE ECEKWPMNDI DKFWMGIPLN
LPALSKPNTF FEAARNGMEF YKHLQAHDGH WPGEYGGPMF LLPGFVIGSY VSGMPFKDPE
RREMIRYLIN MAKEDGGWGL HIEGQSTVFG TGLNYVALRL LGVDAEHPTC AKARAKLHQL
GGCAAIPAWG KFWLALLNVY DWEGVNPVPP ELWLLPEWLP IHPSRWWIHV RQPYLAMSYL
SENLPVRIDS MLIGLQELYT EDYYKIYWPA QRNNIASVDL YAPHSKIYDL INVVLTTYGQ
CPFPPLLNAG INRAYELIVM EDENTSYQTL APVNKMFNLV ARFHREGAGS EAWKQHEIKR
HDFMWLGPEG MRICGTNGSQ LWDIAFITQA CVEMGLAELE ENRECMKKAL EWLDEGQMLD
NPKHFKEAYR MATKGAWGFS TKEQSYLVSD CTAEGMKSVM FLQNHLDYMP KRVSDERLRW
PVDRLLTMQN PGGGGFRRTI RDAIEYIHNA QTPEGGWIGS WGICFTYAAM FATESLSLVG
ETYETSACAR KACDFLLRHQ REDGGWGESY KSCEQSRWVE HEQTQSVQTC WAAMALMHAK
YPHPEPIERA ARLVMSRQNP DGSWPQEAIE GVFNKTCAIS YPNFKFAFPI WMLGKAQKYV
DGLRAKANGN GASHGEY
//
