ID D8Q4D4_SCHCM Unreviewed; 524 AA.
AC D8Q4D4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=SCHCODRAFT_257117 {ECO:0000313|EMBL:EFI96773.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI96773.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; GL377306; EFI96773.1; -; Genomic_DNA.
DR RefSeq; XP_003031676.1; XM_003031630.1.
DR AlphaFoldDB; D8Q4D4; -.
DR STRING; 578458.D8Q4D4; -.
DR GeneID; 9596204; -.
DR KEGG; scm:SCHCO_01189840; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_01189840; -.
DR eggNOG; KOG0023; Eukaryota.
DR HOGENOM; CLU_519865_0_0_1; -.
DR InParanoid; D8Q4D4; -.
DR OMA; CRNQKQY; -.
DR OrthoDB; 820313at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR007274; Cop_transporter.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF18; NADP-DEPENDENT ALCOHOL DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_6G00510); 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF04145; Ctr; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|RuleBase:RU361277}.
FT TRANSMEM 478..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..332
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 524 AA; 56731 MW; A16EE4C106A1B739 CRC64;
MASTLNAVSF TVFKGSPGGK IVQDITHRVL DYDSVLVKVT HSGLCFTDVH FREQNMVLGH
EGVGIVERVG DGCKDLKPGD RVGWGYVQDT CGTCDMCYQG EDMYCPHAAL YGMSNLDVGS
FASHAVIKES FLIRVPEKLD LLHAGPLFCG GATVFEALNR YGVKSTDRVG VIGVGGLGHL
AIQFAAKMGC EVVVFSGTES KREEALGLGA TEFHAVKGVE KFSDVKPIDC LLSTANAQPD
WKLYLDIMAP KGIIFPLTVE LGNYENFPAF PVNIKGITVQ GSCVGSRSLT RRMLDFAARH
GVKPTVQTFP MTKEGIEEAI KVLQEGKMST AMRPLDMLRS IIFISLAWAM TAAAHSHGSD
NGMDMSMDVP IELASGTMVP YLHFNISLGD ILWFYGWVPK HAGPMFAACL GLFLLGILER
WLAMLRVLCE SGWSLPMPAA EPHKGQLPSQ TAPSTRPRSR FIPSIDLPRG LLQVLQSALG
FAFMLAVMTW QVGFILSICI GLGVGEMLFG RIISAVGRAK VASC
//
