ID D8Q9W4_SCHCM Unreviewed; 958 AA.
AC D8Q9W4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SCHCODRAFT_77748 {ECO:0000313|EMBL:EFI95732.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI95732.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL377308; EFI95732.1; -; Genomic_DNA.
DR RefSeq; XP_003030635.1; XM_003030589.1.
DR AlphaFoldDB; D8Q9W4; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02631305; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009187_0_0_1; -.
DR InParanoid; D8Q9W4; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..172
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 197..360
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 372..658
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 910..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 290..317
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 928..942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 108795 MW; EDD59940F9EE1789 CRC64;
MGAIDDAGDL INDDSRTLAP EAVASQVALM SVISVVTVLA FNILRPKNKI IYEPKVKYHV
GNKPPPRISN SLFGWLPPLV HTKEPELMDK VGLDAVTFLR FLRMMRWLFT GIAVLGCGIL
IPINVYYNLK HVDKEGRDIL SMLTIRDVSG NILFAHVAVT YLITFLIIAF VYVHWREMVR
LRHAWFHSEE YQQSFYARTL AVRNVPKKFQ SDEGLKAIFE SVKVPYPTTS VHIGRKVGKL
PELIELHNDT VRQLEEYLVR YLKGGKIGKK RPTIRIGGFM GMGGKKLDAI DYYSDKLRRM
EGAIQEYRRQ IDTRKAENYG FASMAAVPYA HVVAKILSDK HPKGTDISLA PNPKDIVWRN
MNMTDGERAR KSTIGTAILV LVCFFNTVPL FIISILANLS SVRCVLTTWV PFLEKWQEES
SGSFNFVSGV LPPTVSALFG FFLPIIMRKL TRYMGALTHS RLDRAVVARY FAFLVISQLV
VFTLIGVIFN CVKEIIRQVG KKSFSEIIHN LDSTWLTARN LTYIDQSSYW LTYFPLRGFL
VLFDLAQVIN LVWLSFKTHV FGRTPRDIRE WTQPPEFQYA IYYSNTLFMA AVALVFAPLA
PLVALAAAIV FWMSSIVQKY QLMFVFVSKV ESGGRLWNVV INRLLFTVLL MQAMMTLTIG
LQTGWSTFEW CSTLPPILFI FIFKLYLNRT FVYKFKHYEP TPDELRLAKV HSERADLKGN
RLEKRFGHPA LHTELFTPML HKNMMPLLGQ VYGGKMASQD VKMDEYGGKK MEAQVVQGGI
RIAAIDQAQL EYDPALYQRD RGEQDWDAKS MTSTAILDAP SMYNYNMTDS QANLNAARYQ
NYLAQGPSQS EIELAHMDSP HEPLLNPRAQ FVQHGSSMSV NTLGTPPSLY QEPMAAHSTA
GFREAPLHRN MSYDTYGPEA AMEYPPRPQQ QQYPSGYGSD YGAPTQNMAG RGTGRFQQ
//
