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Database: UniProt
Entry: D8QH56_SCHCM
LinkDB: D8QH56_SCHCM
Original site: D8QH56_SCHCM 
ID   D8QH56_SCHCM            Unreviewed;       368 AA.
AC   D8QH56;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   10-APR-2019, entry version 37.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR036497};
DE            Short=HDH {ECO:0000256|PIRNR:PIRNR036497};
DE            EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR036497};
GN   ORFNames=SCHCODRAFT_79193 {ECO:0000313|EMBL:EFI92610.1};
OS   Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Schizophyllaceae;
OC   Schizophyllum.
OX   NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN   [1] {ECO:0000313|EMBL:EFI92610.1, ECO:0000313|Proteomes:UP000007431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX   PubMed=20622885; DOI=10.1038/nbt.1643;
RA   Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E.,
RA   Stajich J.E., de Vries R.P., Record E., Levasseur A., Baker S.E.,
RA   Bartholomew K.A., Coutinho P.M., Erdmann S., Fowler T.J.,
RA   Gathman A.C., Lombard V., Henrissat B., Knabe N., Kuees U.,
RA   Lilly W.W., Lindquist E., Lucas S., Magnuson J.K., Piumi F.,
RA   Raudaskoski M., Salamov A., Schmutz J., Schwarze F.W.M.R.,
RA   vanKuyk P.A., Horton J.S., Grigoriev I.V., Woesten H.A.B.;
RT   "Genome sequence of the model mushroom Schizophyllum commune.";
RL   Nat. Biotechnol. 28:957-963(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036497};
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036497}.
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DR   EMBL; GL377312; EFI92610.1; -; Genomic_DNA.
DR   RefSeq; XP_003027513.1; XM_003027467.1.
DR   STRING; 5334.XP_003027513.1; -.
DR   EnsemblFungi; EFI92610; EFI92610; SCHCODRAFT_79193.
DR   GeneID; 9597285; -.
DR   KEGG; scm:SCHCODRAFT_79193; -.
DR   eggNOG; KOG0455; Eukaryota.
DR   eggNOG; COG0460; LUCA.
DR   InParanoid; D8QH56; -.
DR   KO; K00003; -.
DR   OrthoDB; 998704at2759; -.
DR   Proteomes; UP000007431; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|PIRNR:PIRNR036497};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007431};
KW   Isoleucine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   Methionine biosynthesis {ECO:0000256|PIRNR:PIRNR036497};
KW   NADP {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|PIRSR:PIRSR036497-2};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036497};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW   Threonine biosynthesis {ECO:0000256|PIRNR:PIRNR036497}.
FT   DOMAIN       13    146       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      154    365       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND      13     18       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    226    226       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      95     95       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     119    119       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     211    211       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   368 AA;  38097 MW;  45C95DF788F6011F CRC64;
     MAAPIPVNVA VIGVGLVGSE FISQLLGLPQ PSPFKLISLT SSSRTLFSPS AALAPGADWK
     AALAASSEKP DLAKLTEQLA ALVSPQQKVA IIDNTSSEDV AARYPAWLEK GINVVTPNKK
     AFSGDVALYD ALIGATAKSG AKCFHEATVG AGLPVISTLK DLVATGDKIL KIEGVFSGTM
     SYIFNEFSTG AAGGPAFSAV VKEAREKGYT EPHPADDLNG ADVARKLAIL ARVAAPARDA
     KLPKLGSFAD VATKSLIPAP LEGVKTGDEF VARLPEFDGE FTGLREEASK AGEVLRFVGV
     VDAVKGEVKA GLERYSSTHP FATALGGSDN IIMFHTERYS PRPLIVQGAG AGAAVTAMGV
     LADLLRLV
//
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