ID D8QH60_SCHCM Unreviewed; 417 AA.
AC D8QH60;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
GN ORFNames=SCHCODRAFT_83359 {ECO:0000313|EMBL:EFI92884.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI92884.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
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DR EMBL; GL377312; EFI92884.1; -; Genomic_DNA.
DR RefSeq; XP_003027787.1; XM_003027741.1.
DR AlphaFoldDB; D8QH60; -.
DR GeneID; 9597289; -.
DR KEGG; scm:SCHCO_01134402; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_01134402; -.
DR eggNOG; KOG2733; Eukaryota.
DR HOGENOM; CLU_031002_0_1_1; -.
DR InParanoid; D8QH60; -.
DR OMA; CEYRAIA; -.
DR OrthoDB; 5479972at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 275..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..134
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 417 AA; 45380 MW; 6EAACF10531DD941 CRC64;
MPYDILVLGA TGYTGRLIVR YLYAHHQYRT SFTLAIAGRS QAKLDALIKE EKLDDSVQVL
TVDVLKQEEI DRAVKGAKVV INTVGPFAKW GTPVVRSCVE KNVHYVDISG EGFWIIDIIN
EFHDRARQQG TILVPASGFD CVPSDYNAYL AHKALKSFAP DASLAETISA FVFKSGFSGG
SLATSFNMLE LPKEKLKASQ ADWALSPVKG RPTPHFQLSY RLPHVSPPVY GGQFMMSMVN
RPIVQRTWGL LQEGDPAAAY GPNFKYIEFA RTESWLGGVL LSLSLAIGGF LLSLSPIRAL
AKRFLPAPGE GPPEEDIEGG YFNITTVATS DLLPNGKPPV RVKSYFAGKG NGYQVTAVTT
SEAALAILLD HDKLPALGKK GGILTPVAAL GDVLLDRLRP TGCFEEKVEL IEDRKAV
//
