ID D8QLR8_SCHCM Unreviewed; 759 AA.
AC D8QLR8;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Cellobiose dehydrogenase {ECO:0000313|EMBL:EFI91158.1};
DE EC=1.1.99.18 {ECO:0000313|EMBL:EFI91158.1};
DE Flags: Fragment;
GN ORFNames=SCHCODRAFT_114791 {ECO:0000313|EMBL:EFI91158.1};
OS Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN [1] {ECO:0000313|EMBL:EFI91158.1, ECO:0000313|Proteomes:UP000007431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX PubMed=20622885; DOI=10.1038/nbt.1643;
RA Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA Woesten H.A.B.;
RT "Genome sequence of the model mushroom Schizophyllum commune.";
RL Nat. Biotechnol. 28:957-963(2010).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|RuleBase:RU003968}.
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DR EMBL; GL377319; EFI91158.1; -; Genomic_DNA.
DR RefSeq; XP_003026061.1; XM_003026015.1.
DR AlphaFoldDB; D8QLR8; -.
DR SMR; D8QLR8; -.
DR STRING; 578458.D8QLR8; -.
DR GeneID; 9588658; -.
DR KEGG; scm:SCHCO_02642438; -.
DR VEuPathDB; FungiDB:SCHCODRAFT_02642438; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_011025_0_0_1; -.
DR InParanoid; D8QLR8; -.
DR OMA; IGYLQCA; -.
DR OrthoDB; 52047at2759; -.
DR Proteomes; UP000007431; Unassembled WGS sequence.
DR GO; GO:0047735; F:cellobiose dehydrogenase (acceptor) activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR CDD; cd09630; CDH_like_cytochrome; 1.
DR Gene3D; 2.60.40.1210; Cellobiose dehydrogenase, cytochrome domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR015920; Cellobiose_DH_cyt.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR47190; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR47190:SF5; PX DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF16010; CDH-cyt; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF49344; CBD9-like; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU003968};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003968};
KW Oxidoreductase {ECO:0000313|EMBL:EFI91158.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007431};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..759
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003120955"
FT DOMAIN 312..335
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 479..493
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT REGION 200..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 759
FT /evidence="ECO:0000313|EMBL:EFI91158.1"
SQ SEQUENCE 759 AA; 80663 MW; A36B6F8AF0214721 CRC64;
MLWRAALSAL PLVGCALAQT GAQYTDPDNG ITFWGITDAS HSVTYGYVFP ETDTGEFIGE
IVSPIEGAWV GVSPKGTMLN SLLLVAWANG GEVVHSARIA SGYVLPTPLE GPVITDLPST
TVNATHWKWV YRCQNCTTWD GGSLDPTGSG APAWAYSTKA VDDPSDPDSD FAQHTDFGFY
GLDFASAHAS QADYDNWAAG GTGGGGGSPP TTTTTTTTAP PTATATPDPV DYIVVGAGPA
GIITADRLSE AGKSVLLLER GGPSTGETGG TYSAPWAEGS GLTKFDVPGL FETLFNDANS
FWWCKDVNTF AGCLLGGGTT VNGALYWYPP DIDFSTDNGW PSEWTNHSPY TAKVKERLPS
TDAPSTDGKR YLTQVHDVVA ELLKPLGFSS ITINDEPNRK DHVYGYSAYD FLDGKRAGPV
ATYLQTAQKR ENFKLLMYTN ALNVVRNGTQ ILGVKTNDTS ILDGVYTLNP GGRVILSAGS
LQTPRLLFQS GIGPKDMITL VQGNTDAAPN LPDEADWIDL PVGENVSDNP SVNLVFTHPD
VDSYDNWAEV WDDPRPDDAD QYLKDQSGVL AAASPRLNFW RAYVGSDNVT RYMQGTARPG
AASIDTDNDY NLANVFTITC YLSTGVTSRG RVGIDAALRA GPIVDPWLTD PVDKEVLLTG
IQEIASAIGN VSDLVLITPD NTTTVAAYLD DYDLTAMNSN HWVGSASIGS VVDVNTKVKG
TDNLFVVDAS IIPALPMGNP QGALMSAAEQ AVARILALN
//
