ID D8R6F0_SELML Unreviewed; 781 AA.
AC D8R6F0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Acylamino-acid-releasing enzyme {ECO:0000256|ARBA:ARBA00018421};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
DE AltName: Full=Acyl-peptide hydrolase {ECO:0000256|ARBA:ARBA00032596};
DE AltName: Full=Acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00032284};
GN ORFNames=SELMODRAFT_168303 {ECO:0000313|EMBL:EFJ32660.1};
OS Selaginella moellendorffii (Spikemoss).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Lycopodiopsida; Selaginellales; Selaginellaceae; Selaginella.
OX NCBI_TaxID=88036 {ECO:0000313|Proteomes:UP000001514};
RN [1] {ECO:0000313|EMBL:EFJ32660.1, ECO:0000313|Proteomes:UP000001514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551031; DOI=10.1126/science.1203810;
RA Banks J.A., Nishiyama T., Hasebe M., Bowman J.L., Gribskov M.,
RA dePamphilis C., Albert V.A., Aono N., Aoyama T., Ambrose B.A., Ashton N.W.,
RA Axtell M.J., Barker E., Barker M.S., Bennetzen J.L., Bonawitz N.D.,
RA Chapple C., Cheng C., Correa L.G., Dacre M., DeBarry J., Dreyer I.,
RA Elias M., Engstrom E.M., Estelle M., Feng L., Finet C., Floyd S.K.,
RA Frommer W.B., Fujita T., Gramzow L., Gutensohn M., Harholt J., Hattori M.,
RA Heyl A., Hirai T., Hiwatashi Y., Ishikawa M., Iwata M., Karol K.G.,
RA Koehler B., Kolukisaoglu U., Kubo M., Kurata T., Lalonde S., Li K., Li Y.,
RA Litt A., Lyons E., Manning G., Maruyama T., Michael T.P., Mikami K.,
RA Miyazaki S., Morinaga S., Murata T., Mueller-Roeber B., Nelson D.R.,
RA Obara M., Oguri Y., Olmstead R.G., Onodera N., Petersen B.L., Pils B.,
RA Prigge M., Rensing S.A., Riano-Pachon D.M., Roberts A.W., Sato Y.,
RA Scheller H.V., Schulz B., Schulz C., Shakirov E.V., Shibagaki N.,
RA Shinohara N., Shippen D.E., Soerensen I., Sotooka R., Sugimoto N.,
RA Sugita M., Sumikawa N., Tanurdzic M., Theissen G., Ulvskov P., Wakazuki S.,
RA Weng J.K., Willats W.W., Wipf D., Wolf P.G., Yang L., Zimmer A.D., Zhu Q.,
RA Mitros T., Hellsten U., Loque D., Otillar R., Salamov A., Schmutz J.,
RA Shapiro H., Lindquist E., Lucas S., Rokhsar D., Grigoriev I.V.;
RT "The Selaginella genome identifies genetic changes associated with the
RT evolution of vascular plants.";
RL Science 332:960-963(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; GL377572; EFJ32660.1; -; Genomic_DNA.
DR RefSeq; XP_002966633.1; XM_002966587.1.
DR AlphaFoldDB; D8R6F0; -.
DR STRING; 88036.D8R6F0; -.
DR MEROPS; S09.004; -.
DR EnsemblPlants; EFJ32660; EFJ32660; SELMODRAFT_168303.
DR GeneID; 9652399; -.
DR Gramene; EFJ32660; EFJ32660; SELMODRAFT_168303.
DR KEGG; smo:SELMODRAFT_168303; -.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_014230_1_1_1; -.
DR InParanoid; D8R6F0; -.
DR OMA; QEIATPF; -.
DR OrthoDB; 2877590at2759; -.
DR Proteomes; UP000001514; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008242; F:omega peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001514}.
FT DOMAIN 20..304
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 566..779
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 781 AA; 84102 MW; 6006A105549375AF CRC64;
MELAPAILGS NSAAPQAPQD RQLAKQSELL QSFFGIPSID KAWASPSPRG NGLDVVVAMS
QIDLPGNAKR NFMSHLYLPE AGHGLDPATN CHWSPFPIQL SGASLVVPSP SGSKVLVVCN
TEPASKDSPC SVKLQIWGPM QLLKEVHVPS KLHGSVYTDG WFEGVSWSHD ERFIAYVAEE
PPVDRPVFGQ AMGKDGQKQE GEAGTWKGQG DWMEDWGECY AGKRRPLIYV ADTNSGSVQA
VEGIPQDLSA GQVVWAPSSS EGTQYLVFVA WSSFADNFKT PRKLGMKYCY NRPCALYATA
APMFGSHSLD RTPGAPLKLT ATISSAFSPR FSPDGEFLVF LSAKAAVDSG AHCATNSLHC
VKWSGGDSLG TLPPARDVVP VISRPDAKGF PGLYCSTFLS HPWLYDNRTL LLTSAWRSTQ
VIVSVNLESG EVLRLTPEDS ISSWSLLSVF KNILLAVASN PGSPPDLKIA YCSSMEKISD
AAFQWSDIPT PVEHTEEVQS ILSSISSRIL QIPVPSSDGN EILPQGAKDP FEAIFVSPGE
VKEGSEPPPL VLVLHGGPHS VSVTGFSRNY AFLVGLGFSL LHVNYRGSLG FGEEALQCLL
GNVGRRDVND VLTALDVVLA EGLAKPDKVA VVGGSHGGFL TSHLIGQAPG RFVTGIVRNP
VCNISSMVGI TDIPDWCYME SYGKAGLNLY DEAPSVKHLG AFYQASPIAH VDKVQVPTMF
LLGAQDRRVP VSNGLQYAQA LRARGLEVKV IVFPDDIHAI DRPQSDFESF VNIGAWLKRF
T
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