ID D8SQ31_SELML Unreviewed; 711 AA.
AC D8SQ31;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Nucleobase-ascorbate transporter 12 {ECO:0008006|Google:ProtNLM};
GN ORFNames=SELMODRAFT_122159 {ECO:0000313|EMBL:EFJ13593.1};
OS Selaginella moellendorffii (Spikemoss).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Lycopodiopsida; Selaginellales; Selaginellaceae; Selaginella.
OX NCBI_TaxID=88036 {ECO:0000313|Proteomes:UP000001514};
RN [1] {ECO:0000313|EMBL:EFJ13593.1, ECO:0000313|Proteomes:UP000001514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551031; DOI=10.1126/science.1203810;
RA Banks J.A., Nishiyama T., Hasebe M., Bowman J.L., Gribskov M.,
RA dePamphilis C., Albert V.A., Aono N., Aoyama T., Ambrose B.A., Ashton N.W.,
RA Axtell M.J., Barker E., Barker M.S., Bennetzen J.L., Bonawitz N.D.,
RA Chapple C., Cheng C., Correa L.G., Dacre M., DeBarry J., Dreyer I.,
RA Elias M., Engstrom E.M., Estelle M., Feng L., Finet C., Floyd S.K.,
RA Frommer W.B., Fujita T., Gramzow L., Gutensohn M., Harholt J., Hattori M.,
RA Heyl A., Hirai T., Hiwatashi Y., Ishikawa M., Iwata M., Karol K.G.,
RA Koehler B., Kolukisaoglu U., Kubo M., Kurata T., Lalonde S., Li K., Li Y.,
RA Litt A., Lyons E., Manning G., Maruyama T., Michael T.P., Mikami K.,
RA Miyazaki S., Morinaga S., Murata T., Mueller-Roeber B., Nelson D.R.,
RA Obara M., Oguri Y., Olmstead R.G., Onodera N., Petersen B.L., Pils B.,
RA Prigge M., Rensing S.A., Riano-Pachon D.M., Roberts A.W., Sato Y.,
RA Scheller H.V., Schulz B., Schulz C., Shakirov E.V., Shibagaki N.,
RA Shinohara N., Shippen D.E., Soerensen I., Sotooka R., Sugimoto N.,
RA Sugita M., Sumikawa N., Tanurdzic M., Theissen G., Ulvskov P., Wakazuki S.,
RA Weng J.K., Willats W.W., Wipf D., Wolf P.G., Yang L., Zimmer A.D., Zhu Q.,
RA Mitros T., Hellsten U., Loque D., Otillar R., Salamov A., Schmutz J.,
RA Shapiro H., Lindquist E., Lucas S., Rokhsar D., Grigoriev I.V.;
RT "The Selaginella genome identifies genetic changes associated with the
RT evolution of vascular plants.";
RL Science 332:960-963(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; GL377632; EFJ13593.1; -; Genomic_DNA.
DR RefSeq; XP_002985463.1; XM_002985417.1.
DR AlphaFoldDB; D8SQ31; -.
DR STRING; 88036.D8SQ31; -.
DR EnsemblPlants; EFJ13593; EFJ13593; SELMODRAFT_122159.
DR GeneID; 9649895; -.
DR Gramene; EFJ13593; EFJ13593; SELMODRAFT_122159.
DR KEGG; smo:SELMODRAFT_122159; -.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_2_1; -.
DR InParanoid; D8SQ31; -.
DR OMA; VSRHAHM; -.
DR OrthoDB; 345287at2759; -.
DR Proteomes; UP000001514; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF28; NUCLEOBASE-ASCORBATE TRANSPORTER 12; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001514};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 76137 MW; 7DC99E37E8F426FE CRC64;
MPLPPPAGLG TSSPPSRAQD HHDPESPSLG RRPGPWPPRM DAGGNQNPRT MGSWARRTGF
RSNMSGESAA STISDTDVSN ADATLHLKAP NSADLSGGAA PRTPVENGSS AKDPGATPTK
VYTPPVSSKR GTGGIDSENV SGVQQSSGQL RGHYRDSEVD MGSQQDMDDV LMAKQSHMKY
EIRETPGLVP LILYGLQHYF SIVGSLVLTP LIFVPAMGGS NEDVAKVVST MLLVTGITTL
LHSFFGSRLP LVQGASFAYL APILTIIHSP EFSSVRQNRF KHIMRELQGA VIISSVFQMV
VGYTGLMSII LRVINPVVVA PTVAAIGLAF FSYAFPVVGT CVEIGLPQLL IVLFFALYLR
KISVFGHRIF QVYAVPLGLG IIWAYAFLLT ETGAYNYKGC NMKLPPSAAC QRHVFTMKHC
RTDVSTALKD AAWFRFPYPL QWGTPRFSFK TGLVMMAASI IATVDSVGTY HATSLLVASR
APSPGVVSRS IGLEGITSAL AGIFGTGAGA TTLTENVHTI AVTKMGSRRA VEFGACVLII
LALVGKVGAF IASIPTVIVA GLLAFMWTLL TALGLSNLRY SETGSSRNVL IVGLSLFTAL
SVPAYFQQYG NAGVNAVTEP YFQPYAVAQH GPVKTKNHGA NFVLNSVLSM HMVIAFLVAF
VLDNTVPGSR QERGVYIWCR PRSARNEPAV VKDYGLPVGR KLFSKVKWVG L
//
