ID D8TLQ5_VOLCA Unreviewed; 797 AA.
AC D8TLQ5;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Fe2OG dioxygenase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VOLCADRAFT_120451 {ECO:0000313|EMBL:EFJ51369.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ51369.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate +
CC trans-4-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:18945, Rhea:RHEA-
CC COMP:11676, Rhea:RHEA-COMP:11680, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.2;
CC Evidence={ECO:0000256|ARBA:ARBA00024151};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
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DR EMBL; GL378327; EFJ51369.1; -; Genomic_DNA.
DR RefSeq; XP_002947321.1; XM_002947275.1.
DR AlphaFoldDB; D8TLQ5; -.
DR STRING; 3068.D8TLQ5; -.
DR GeneID; 9620424; -.
DR KEGG; vcn:VOLCADRAFT_120451; -.
DR eggNOG; KOG1591; Eukaryota.
DR InParanoid; D8TLQ5; -.
DR OrthoDB; 325120at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR006189; CHASE_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR003582; ShKT_dom.
DR PANTHER; PTHR10869:SF207; P4HA_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR SMART; SM00254; ShKT; 1.
DR PROSITE; PS50839; CHASE; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS51670; SHKT; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058}.
FT DOMAIN 111..188
FT /note="CHASE"
FT /evidence="ECO:0000259|PROSITE:PS50839"
FT DOMAIN 576..704
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 720..757
FT /note="ShKT"
FT /evidence="ECO:0000259|PROSITE:PS51670"
FT REGION 141..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 85842 MW; 9C7292700EF1EB4C CRC64;
MAIGALRIPV RIADSYVRPG DEQRLFPNVP EYLCLEDILS AWPRGLITHE KFLHKGTFWR
LMKRPMANGN SVYMAVIDDP GSANGNGAAN GHLSARCTTP DSSAHRLRSM PVDGFSPVHD
GSASDLVGTD YISDVPAQRS QYHRGPLSAQ HSFHHAPSAP APLSSHGSAQ HQLQQRNGDL
VLQPYHSSGP AGLRERNTSY NSMAIVPSQP SGGISPSQLT PGSFSLGCGG NGFMTDLLAA
TESPMPLDRF KAFVRLFSTL GRMREALRLP ATTPRAAAED VADPAWESPE AQDLVRQLLM
TRCETNDLLF NQLIKHVGQE PAAGGAVVFN NSNVTANPTN HMLAAPRTFV NTVSNAWSKA
DVKRRTQLGA LGGVAVVALW VLKRKLFGGG GGGGGGGRGR YGRPDDSEWG GGGSGRRIRY
SSSPNPISAD SSGAPSSGDP LKVSSRPYSS SRQPGAPASW RSAWCGLLAG WGPGPSRQGL
GQKRDRYGPE PWIETISWSP RAFVYHNFLT SAECDHLVQI GTQRVSRSLV VDSQTGQSKL
DDIRTSYGAA FGRGEDPVIA EIEERIAEWT HLPPEHGEPM QILRYVDGQK YDAHWDWFDD
PVHHRSYLVD GNRYATVLLY LSEVEAGGET NLPLADPIDM SVQAIENPSP CAAKMGLSIR
PRKGDALLFY DMDIEGQKGD RKALHASCPT LKGMKWTATK WIHSKPYMGR FDPLRTAGVC
RDTAQDCAAL VAEGRCTSDL DTMVGPAGKC RKSCGDCVDC PNGDILCARR NMRSLVLAKL
NAAKGKSSSS SSGGGAP
//
