ID D8TSA1_VOLCA Unreviewed; 1617 AA.
AC D8TSA1;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=ERD4-related membrane protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VOLCADRAFT_104236 {ECO:0000313|EMBL:EFJ49655.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ49655.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; GL378334; EFJ49655.1; -; Genomic_DNA.
DR RefSeq; XP_002949162.1; XM_002949116.1.
DR GeneID; 9616118; -.
DR KEGG; vcn:VOLCADRAFT_104236; -.
DR eggNOG; KOG1134; Eukaryota.
DR InParanoid; D8TSA1; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1304..1329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1350..1375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1395..1415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1451..1472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1478..1499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1511..1531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1537..1554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..203
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 1038..1187
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 1300..1530
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 264..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..293
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1617 AA; 175661 MW; 1D9E31BA3F6A5B9E CRC64;
MLVANASQCL NILLVAIAKI KDMSDKSVVN TALGRIIGVK NQVSDTTIIT GLWISGVVGT
AVIILFCVLQ RVSLLYKYRL VANHVRVKPP KLRERGLISF IDWAIKSISV SDVDFILSAG
LDALIMVKIC ALGVQLFLPL CILGTAVLIP LHWTGGASKQ LDAYQSGFMR LTMSNIPHGS
KVFWVHLGFV YIYLGWAMVL LHWHYHQYLT IRQHYLRKGD DVNLWRALYE EQGRPDPPQG
KEPRGSEFIN GLLRSVQLIK ALMPSGVPVS GPTSLPADGR DEEDEDEEED EGFAMGGMPL
PLELRRTTLG GLDPVGARSP RGSVDGCGRV VHVRGHGDLW AGEWSQSRVL QLSGAHDAPT
AGSGTSSRLS RRTLAQAIRN RVTGSGSTVL RASGAQDHGS RLIHRAAYSI GPRAVAAPSD
QALQHMRPQL SLDRGGRRGM SPARGQSYLK SSEPVSLQLK ESSDAAAGCG LGQEGATDLE
AGLGRSVLGA DSRSLAPSPC SIDRKGSGLD SDAHLLEWWL ERPEATVQSR SRALRAQLEK
ALNGRDMDLK RPSVGHRKTV NAEFSDGTRV AVLAQHYAVL VTDVTSRRPR LSRRNSRGPA
QPTLVTLPGS EAADAVTEVQ VTGRRPAGCC LPPWLWSWCD LQYGHQAARK LNPKLPATLS
EELLAPVPSG ANRTIASMTA LARGSTPYHC SPRGSGDGRV VPALLSGNRT CSVNTPSHAQ
PLSALQTTST AGRIDLNPDS SPKMAGRWHQ AVRGAALLGR APQGGTWSGS GSGSGSERLI
RLLEMMAREA QGKLAAMSTG IVSANPSLSR GSPSSHHTGT GSGTGTSHPV PTSSVRAVAL
PRSFGTGPSS SHQQLQHQGV PHRFTEPGPA AAAASGGQAA ARRGQAASPR AGSGPIIISP
RVPVGASLRG VAALGQREGP STSGTGAGPV AEASLEIREE GQAGDAAGSE GVIQEGNHVA
GSAGASAAAG VGAGAGQDGG RTVVDAATSQ RQEGSPPGDE VEANPVSQQP TERERLRAAA
LAGWEVVRQA VWDGRVAELP WRYRYSVVSA TFLRLFPEEF DRAIQVVNFK EVDLLLMEVD
KHMAQYEYAI KYEEKTGKPL YGCLGFCGLV GERCRVRDHH RDKINDLLVQ VRKARVAAAN
KAHTPSWFVF FRTQRAAAMA SQCIIHAEDN RQFRVHPAPG PDEVNWSALW SNFRDRDLRR
NLMRPLVVLM VAFPIGIFTG GVTQLDYLLC PAHLCVGLES GSEDWVAAGC TDDIKERESA
DIKTRCTLAG KTLFGVAHAP SQQLSWEWYC GQKNPIARLL KRLVVAWLPS LLLILWQGMV
LPLFFTFVVQ ISRQARSLSE ADRYIAKNMF YFGVFNVFLG GVAGSTIIQG INSAIEKGPS
EIFNLVGTYV PTSSNFFINY TMFRVFVSVP VRMLWPHIGI RMYLIRRYLR LSCIITRRER
AFLMAPVSPR YGFEVGMVMI IFLIAFAFSV VSPLLMPMAM LFFAISWLFW RWALLYVYVR
KYEGGGTMWP FVFNRVLVCL AIFPAFTACV FVTKHAYAQA IVLLVTVPVI LVRFHKYCYY
RFETGLQAMP LEATVAAPPA RVEPWVYTPP PLLSNLAGWH PDWSKCWMGW NMPVMYG
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