ID D8TZG3_VOLCA Unreviewed; 4357 AA.
AC D8TZG3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Fibrocystin-L {ECO:0008006|Google:ProtNLM};
GN ORFNames=VOLCADRAFT_92358 {ECO:0000313|EMBL:EFJ47178.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ47178.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
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DR EMBL; GL378346; EFJ47178.1; -; Genomic_DNA.
DR RefSeq; XP_002951727.1; XM_002951681.1.
DR STRING; 3068.D8TZG3; -.
DR GeneID; 9615901; -.
DR KEGG; vcn:VOLCADRAFT_92358; -.
DR eggNOG; ENOG502QUGT; Eukaryota.
DR InParanoid; D8TZG3; -.
DR OrthoDB; 316276at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR CDD; cd00603; IPT_PCSR; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF01833; TIG; 6.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 6.
DR SMART; SM00710; PbH1; 11.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF81296; E set domains; 7.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..4357
FT /note="Fibrocystin-L"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003124038"
FT DOMAIN 298..462
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 1463..1620
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2226..2346
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 3098..3229
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT REGION 4112..4142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4171..4190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4254..4357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4115..4142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4254..4300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4357 AA; 463586 MW; 4413D2E18F3F055C CRC64;
MFALGLAILL CIASLLQVAV GQPVISRIDP AIGSLAGGAR LVIYGNNFGD MYTTSRSVYI
GPYPCNIISH YSSNEVLTCE TSPGSAALKA VLPRAGPPGT EVFIYGDRTA YMMYRDCVES
NWGDMNCVGS ILFGDYLCRQ DPADPDSPII MTTNPRLGPY LYRIGCTMPA QNSNNTQPAL
GKAASLNATI HFEASMRGGA PTALPSSFLY NVDSVPYQFQ LYPEVTGVSP ATGSNAGGTL
VKVTGRGFPD LRLGMNDTIA ISIAGVPCDI VNSTYDTLFC VTGPKPAATV SPIGGLYPAM
RGIEYEFYNI SRLSYGNLWQ LNNTIKVQPL NGSYRAVLTG SWEGNEYSTP YYCSRSKAFF
TAPRAGNYSF YMSADDYAQL NGTWKQSNGA LVSTTLINLQ SWTYIDNFFQ SPSQRSLEVT
LNAGQSILLE MNHCNGASVG FTQLAVRMPV PEPRLNSLPE IQKISISATF FPRSVAIKYL
YGDGAAVTAF NITISALNDT ALDDPQIGLY VQINGGWDIV LPLGATTGAM DDLVEASLGG
NFTKNDTLFG IRKTRAYGTL TLQMAALDGS MGSFNVTAAR LVLLPPPPPP MDNTCPSNSS
AAINVTSMYP PPAPQALQSA GTGFTVNVSR AQAVPAVVPT GDFLLGLYGN ATTSRVSATA
NSTAMVAAIQ NVTGYNSNYY SVNVTNAREG AYFARIWNIT FTYSWLDNVP ALVVGPSSTT
PPGVLLTMES RSASPRLKGS FKVAFGSSCA SVKINLGDSS ETIEAALGSL PGLAPPKQVD
VSGDGTSGYV YTITFDPINN PGDQPELRIA DASDLQGVNP TGSITTVWNG TTDAFYAPIP
TEFLRLAVSQ PGTINLQVNG VPSACADASG ICGFLYSDAA TPRITGVSPT RLAFSSQASL
PLTITGSGFS SGPSVEVRVG TALCNVTSVT ATQITCNVPD TAPAGVRLVS VNVAGLGFAD
GAPNVTLETL YVTGSAPSPA VLSSAGISVL NFTGKGFDYV DCANNKLTIG GVRCSIIKCQ
PNMLTVIYPG NNGANAAAAS VTAEVYEKGQ LIDSDTPSGL TVSVSSSAPS ISTVSPARLP
GAGGVITWSL TGATASQVIS ASMVPFISSF TNYTEASVAF QEPIPCTDVT AGSSGTLTCI
SPALRNGRYH ILAVLSSGLQ LLSSDTILFE LFITSVSPNL GSIGGGTTLT ITGSGFSQVV
SENVVFITVP VSTTFLNGVV QCIATSVTST TLTCKTLPNL AADASANDPF AKQVMPVDTT
PGRAVSVVIC DSSYNSSFLQ EYCWSLPETA RARCDAAGAA TCNFGYSTEL TPAVDYLYPS
SGSLGTRITV VGSYLNMVTE VQFLQGGVLK GAGSNIISSR TNVSCDAPDL PPGVYTILLL
KANGEKSVDP YGKGTFTFTA SIDRLTRNVG SLAGGLPLVL SVGGAGLAVG PDNLTANAIT
IADLPCPILS VKNRTEVTCR APGMNGYVFA EYWNLGVSTS SMPDIFSFTK PHISRIEKGT
SFSWGTMSPE PGVINFDYWA ARFTFYYQIS VTENVTFYMY ADDDARLYID DVLVGGRNTP
LDTILYPGLR KLVVTHVEYN GGAYLSVVIS RRQPNGARGP FAYLEWQKVT PVPPGTPLPV
KLTVNGIDSV TQCPVTNLTL VLPGQPKAPF EPSWVQTPNR TCSYVYSVYR TPSLSALSGI
TLSGIMQPTF NSTNTTLSIF GDFLTDPSLP AASQISVTLA NRLCSIVGVA PVTVNGTNTT
NINCTAPALP AGQWPVSIMV EGLGLTRPTA TAATDLPIVT YTVRVLSYTF NNPNSKCYFS
LFGGGTFNIT GYGFVKDLVD TTLQVNMTAA WETVFCGSGF SNSPPCQAVN SSRLNLVPLA
SDGFTASFGL TRFKVPNPEA FAGNNSISGV NLRYKPRVYY TSNGTYAATA SIELLYFCGG
RTPALSGVTP SSAPPDAGAT LSLTWYLSGV GTLNNIITAP AAKNGASNAT VEFEVGPTVL
PCRNPVVTDF NITSTTYREA ISCTMPAYMP AATYTLWLCI QPFGCGLLPA YTIPLTISAM
SATTGGSAGG ITVVITGKGF DTNTTLVSVR FGNSTCKVIS STATSLTCVT GPLDTKPVSP
VTWPLSITPT AGTNETTLSN FTFTFDPALE STVSGIVPAR GSTEGGTPVT ITGADFRTGV
STTVSIGDVA CQSVVVVNST AITCTTGKPP NSILRVPLPV TVLQQGRGYA RSSAQYQYID
VWSRNSTWGG GPLPGYEDSV VIPAGVTVLL DISPPKLYVI VLEGNLVFDD TKDYINLQAH
YIIVKGGNFT IGSAEKPYPG RANITMHGAP NSRDLPMYGA KALAVRQGVV TFFGQPKIPH
YTKLNRTADP GDTSIVVNGA INWQVGDRIV IASSSFYGNE VDEATITALD NRTVSGCTVI
TLDTPLQYVH LGELHSVQGS TPLDMRAEVA VLTRNILLQG DYTSAKNMYG VQVMVNSPSY
LTNKGLVRFD NIEITQSGQA FRLGRYSMHW HLMGDVAWQT WVRGCAIHHT YNRAITVHGT
HRAIIQNVTA YHTMGHTFFL EDGIESGNLI EGNLAIHVKV SDALLNTDTS PAAFWITNPN
NTVRNNVAAG SAAYGYWYRM LDNPEGPSYT TTICPKFTPL LEFTNNTAHS SMFYGLRIHP
EFYPRNVPCN GFSGTFEQVP AVFNGLVAYK NGMKGAVGTQ VGMVQLVNVI AGDNGGGPQQ
HVVNGKDHGG DLELSWVVDD RSRVGVQITE MAGIVNATIY SRTSVGKRGS AGQWPSCRRV
AGIITQSPVK GDPKHSALMS LINVTFVDFK GWDDCTLFSM LEACGKCKDH QGGSTTFTAN
ISIITSDNSS SMMSYWSWGH QGVYLDTDGT LLNNKSLPAS LLPNVGTNVT LGPGATWHSS
VESELFDPNE CKYVRNTRTS NNGAYCSPGL SFRRVMLHDH TPQSIGIKDL ILTSVATNRS
SLVHFTKYNE FGYQFTIATA RDYWVQWDMP FRVDPETYEL HKMDLMNTSD YVYITTKHIQ
VKDHFSINNN DQWNNLTAMP PPTNSTHGMF YYNKTKAPNS WWWSNLSYYD TKFTVFVDGR
LDTALDMKAF TCPNTGCTNV PDAVVDTRNN TLYWSNTSTW NTSAVNNFRK PVAGDNVTIP
YGWDLVIDES TPPLLALTVQ GNLRFDTTRD INLTATYIIV MGQGVLSAGS ATEPHPAKAT
IRLKGARDTP DYGIDNNFNL GSKVLAALAG GTINLYGKPA RKRWIKLGSA AQIGNNAINV
SDPNHGWSVG DKILITSTSF NWNQSEFRII TGIRNNGSQL LLDSPLAHPH GARVKAYPGG
PTVDMRAEVG LVSSNVLITA DDGESTHSYN GEMFGARVVV SGNSTGRFDS MGMAYCGQAG
FDDRACIYFD RMAPVTVMRT DNVTKITTVS AVPNPSFVKG SVLLYGMASN VLIYGNPSVA
SPVTLADNIM YEAFDKHSVD VQTRDNVIRS NLVIGTIKNM TERSGNDVRM PSSFRIVYAS
NWVTDNVAAG SERYGFAYYG LPCSNFTNGS FRNNTAHSSL AGLWFQASPE ALLQGCAQLT
NFTTYMNWDF GIISTHGVST DIVLKDVNIL DTKHAGIHLM RYGEMTDKGW MRWDGGLLVG
QSSNDVCSAC TKRGDPGCHP KMSLQSFNQY DPFTPAVGLQ SSQFALGFAV GPEKKPFDKP
MGYSLIHGMF NISGITLADF LGPAGCGGSQ SGTYALANQP KAPEAFYPHY FSKINVQNVS
TGVNQGMFYH TPPDPDWRNE ADCGEAVYTR PDGSQIKLNC AGPAHAYWRD LDGSLTGTVS
TTAGIFTSKR VFPMDQGSPV LPGACTYSEY QDSYQCVVNS TSYIAEAGLD LRYKPDPVPA
DGIWGDPQML VLESRDKDTE DRNFGPVFFN VSGSIDLVTA AMDHGWCFAY TCQKRLSTFW
TYVPTGQTVY INFTRTPSQS FRIWFPYADP DKEIVLVINM LYTLNRRFTW LPPGNGNTTG
RVMPLDKPIR IGDGTPHGSY FWDQDNALLY VKIKGGMTVE TRTESAVMVS QSFAVTIDNF
YAQQAVFLKN LAAVMGIDMN RLYVAKIVAG SVSATIGLEP DKSIPVDPLL DNTVSAAVDP
TDPVVTDPAI TAANSSIVAV FVVRRRAKGP LPVLPSGSPS TSEVSSSMSS PPAAGRPGSA
STRQAFVATN PAYETPGERA AALPASVAAV PVQGPEENPT SPRASVLAAG PTPLSPAQFI
GPLASTARMP HSSLPLVPPR TPVAAVDAME GEAMLAPGAS VSVAAAASGA IATTASGSVG
GSRSPAQLTP GQPTTNHPSD TTVTSPSNMA TGSTGSKVDS AEIEQVPDHD QTKAAAAEGA
PAAVHVVAPP GTSPAPVTGD ATDAATTPKA RMPASLQ
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