ID D8U2L0_VOLCA Unreviewed; 626 AA.
AC D8U2L0;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0000259|Pfam:PF01699};
GN ORFNames=VOLCADRAFT_93618 {ECO:0000313|EMBL:EFJ46155.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ46155.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily.
CC {ECO:0000256|ARBA:ARBA00038187}.
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DR EMBL; GL378353; EFJ46155.1; -; Genomic_DNA.
DR RefSeq; XP_002952905.1; XM_002952859.1.
DR AlphaFoldDB; D8U2L0; -.
DR GeneID; 9627565; -.
DR KEGG; vcn:VOLCADRAFT_93618; -.
DR eggNOG; KOG2399; Eukaryota.
DR InParanoid; D8U2L0; -.
DR OrthoDB; 317278at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..626
FT /note="Sodium/calcium exchanger membrane region domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003124105"
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..194
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 469..582
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 241..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 67335 MW; 720DDF56EEC82C2B CRC64;
MVQLCPALVL ALLAAGAAAE PYTCDRLHEV PPGKRCQFVT EQCDSEGGLP YTRWYYCSVE
PHGVAASCFF TVLLACLLPL LFTLLGDTAE MYFSPIMTHV SQSIPKMRPR FAGVTFVAIG
NGATDLSANI TAIRNGDVLL SAGALTGAAM FVQCVVASEV MRASRGPVKC GGATLRDLGI
YIASVVLVLT SFAYGKVRMG EDNLLVYRWC RTAVLVVRGV GFLGDEWLRG DVRGRPWCGG
VSASSVSSRR GADEDASTDY GTESYSDNDD DAEEGLLESQ RRRRRRHAAF EEGECPVEED
GGGGLTAAVA GPSSSGLRSV LVLESTGRPN SRAGERRRGC WSKLQYELTV GNSAEWEELP
VDSLRRRWRT VTFPVLLPFY AALRFSIPFV DPATYSRRWL IATCLGGPLL VAFYMAPAAW
RLQLLAAVLA LTVGAVLAAA VAYFTAGEED ALPDWDLGTS FAFGPAFFAV FGFFMGIIWI
DLLASEVVGV ISLLASLLRL PASVMGLTLL AWGNSLGDFF GNPAMARRGK PTMALTACFA
GPLFNMLTSL ALGFGSYLAQ SSQTHVRVVL RPEVALGCGF LVMYNLAVAA AGLMNHGSLP
ERFYLFARGW YLAYLATACV VGLWTG
//
