ID D8UK42_VOLCA Unreviewed; 2736 AA.
AC D8UK42;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFJ39887.1};
GN ORFNames=VOLCADRAFT_108435 {ECO:0000313|EMBL:EFJ39887.1};
OS Volvox carteri f. nagariensis.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Volvocaceae; Volvox.
OX NCBI_TaxID=3068 {ECO:0000313|Proteomes:UP000001058};
RN [1] {ECO:0000313|EMBL:EFJ39887.1, ECO:0000313|Proteomes:UP000001058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=f. Nagariensis / Eve {ECO:0000313|Proteomes:UP000001058};
RX PubMed=20616280; DOI=10.1126/science.1188800;
RA Prochnik S.E., Umen J., Nedelcu A.M., Hallmann A., Miller S.M., Nishii I.,
RA Ferris P., Kuo A., Mitros T., Fritz-Laylin L.K., Hellsten U., Chapman J.,
RA Simakov O., Rensing S.A., Terry A., Pangilinan J., Kapitonov V., Jurka J.,
RA Salamov A., Shapiro H., Schmutz J., Grimwood J., Lindquist E., Lucas S.,
RA Grigoriev I.V., Schmitt R., Kirk D., Rokhsar D.S.;
RT "Genomic analysis of organismal complexity in the multicellular green alga
RT Volvox carteri.";
RL Science 329:223-226(2010).
CC -!- FUNCTION: Protein transport. Probably involved in vesicular traffic.
CC {ECO:0000256|ARBA:ARBA00025673}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; GL378438; EFJ39887.1; -; Genomic_DNA.
DR RefSeq; XP_002959026.1; XM_002958980.1.
DR STRING; 3068.D8UK42; -.
DR GeneID; 9625772; -.
DR KEGG; vcn:VOLCADRAFT_108435; -.
DR eggNOG; KOG0950; Eukaryota.
DR InParanoid; D8UK42; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000001058; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08638; DNA_pol_A_theta; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001058}.
FT DOMAIN 857..1065
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1108..1321
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 145..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1613..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1874..1893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1901..1966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2457..2483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2736 AA; 285722 MW; F5C8C871461B3F6E CRC64;
MISRSGQLHA KLPLNRRIRL GVRLTQPCPR ANSTSFVCDA QLSRSAVSRP AVSLIDAPGD
TPPLQHGAAS SGHPVVGLLS ADPCRVPALR LSNASFVAET PDASPLTHDE GVPATPTEEL
GIFLACGAAL GPHAQLDYTS ARDSQLLYHE QQRQPVEAQQ HEQQPDPEAK WTAHLAAAST
LLEPQARCWV QDPSSITGRN TFQQPRPPQS SPRSRAGNPQ GSFPDYIGIA AEAPAAELPL
RPTSQVSWQA RGAPAVTATL ETAGASVPPT TSVSVYEPRP RSPSYRSSSR PTSANAAAAS
PKLSALPAVA PAPSAKSGPG FASLTMTRGS PVATGTGRVA AGRQPGGNHI VVDPRRGAMV
CSPTARVPSA GSGQPRSPPG ATSASAPGGQ QQLQALSTSP SRHQHPPSVN HYPGLALAPC
KPSPRGVEGE LAPVAANVGS TAADGRPSRV RVLNLGVSNR LHTYAVSPHV GGEQDQALPG
TRVSAVALPA FQHLRATGVM VAGAAAGSSA ATPLPPALRQ QATAAAAAAA PAAQDRTPAG
QPLRGVYGTG GCTVPPSSAK STPFDEEMLA VLDSLERRIG NAAAAAAVHG APVPWAPTAA
AATRPGFCTE ANVLPPACDG AAPGNVVETG VTPQAALRGV LQSAVAVGAT PELESAGLLA
ALDAIEERHR LAEAAAAAAA AAAEAVNGGA APQAGAATAV GIAVHGSVTA PGGMGRGGGG
GSGDDSSSSS SDDEEAEHAE AYAAPLTQRA LVEGHVRQGR SQRPSRNLLA SMAAASGETP
EGNGGRGGDG GDLQAEVADV CGVAGGTAEL VDEPPPPPPA PPRQLEAYLP APLCQAYYER
GGGRFELYEW QAECLCQLGV LMGRNLVYCA PTSGGKSMVA EMLGLRRLLT TAAPPRGKPF
LLVLPFVALC AEKAEALGAL LAPLGRGVNC AYGGQQNGKI IQPGVGAIVA TIEKANMLVN
IMLEEDTLGE LSAVIVDELH MVGEEERGYL LELLLTKLRF ATSASAGEGG GGGGGGGEAE
EVPFDWTAVG PSYLREGLQV IGMSATMPNV DVVATWLDAA LYCTTFRPVQ LQEYVKVGRR
ILDSSGGLIR ELVPDKAWED RDADHVALLT AETVREGHSV LIFCASKILC EKVADHIARM
LQIGQREPPP VTAAAGGGGG GGGGADGASP PRNTRESYVG ELRRLAGADP TLADLVARGV
AYHHAGLSNE ERDLVEAAYK AGAISVLTAT STLAAGVNLP ARRVIFRHTY IGKQDNPIDA
TKYRQMSGRA GRAGIDTAGE SYLICERNKP VAPLLALMQQ KASAIGSCLT EARKGMKRAV
LEVVASGAVS SGGDVKRFIG CTLLHAQYGF QAVAKATIAA LHWLKDNGFI RVDEGSLNWG
PTPFGKATLA SSMPPEDALV VRADLERARM SLVLATDLHV TYLVTPIKED LRVDWQIYFD
WFEKLSRVDA RVAELVGVVP AYLVKLRQGH RGARVGGGGG AADAEKERIA RRFFAAMVLN
DLIQEVPLKE VAEKYGLGKE KGPLEGLQER AGRFAAMVAA FCERLGWADL EVIIAKFQSR
VWYGVRPEVV ALTEIPYVKG HRARLLFKAG LRTPEAVAGC ELERLIEILS AGAPRNPEHE
EQQRRTERRA ARMILQGAKD LVNQKVHELK EQAKALRAAL DPSASQQHSV PLDASLAPPQ
PPPQPRQQQQ QPQSQSQLHP AAAEALGRQH GGPVEETHHV GSTVPAAAAA AAAPTALATA
MPVDGRCGSG SGGGSGAAGA AELGDGCMGK ARPSGATPVR PTKQQRREGG DQQGLDAAET
ASTTPAPAPV LAAPATAAVL AADVAVQDRQ RPDALAAQGH TFGHTAIPVT HVSDGQLPDH
NASSALGKSM MITKSTEISS SRSSRSSQNS FAMIRKSSVG TLVNKDSRSS TTTTTSSKQT
MLLQQQQEQQ LSRAMGSGGA GSGGGGGGTL ATAGPPGAPP SPQTRFPLLH VPGFTVLKTT
TEVAAVCEQL RQVGMWGFAL DFADGSTVPP SSGAAGVMAL PSVPQVALGR GVMVNSIGLP
LHYDMEEPLA LDAAGGSGGS GGGGGCRLEG ISLCAFDGCG LYVPLVAATE VAAAEPATAA
ERAAREAAAV LSEVRQLLAH AGSTKVTFEL KQQLMHARAA LGAVAMSAAA APEGPLPAAP
AADLPLLVGD PVVDVRILLW MLNPDDPVNL PRGKSGKLTA TKGLEERMKQ PEVCGTSGHA
KALGALHCAG AVVRQLPTRQ ADACRRAAMA RRIYLDKLPK LQSEGLLRPL LEVEMPLVRI
LAAMEATGVA LAPRVLRDQR GPLEARLRQL AHKAHVAAGM TFDLNSPKDV SEVLFQHLNL
QPPPCAFTSH HQKHPSTKXE VLEELEESTH HPILRYLLDY RSLHKLLTGF VETLYSTARG
QLCGSWLHTA TATGRLSMDE PNLQTIPRPV EYCFQLSQEE SPRATTEMAV GVAGAEGQVP
PLQPLQPAQG DGGEEAGGGG GGGGCRTVVR MHFNLRNAFV APPGHVILTA DYKQIELRLM
AHFSGDSALC DLLRNPAQDP FTLLAAEWKR LSVEQVTPEV RVQAKRLAYG MLYGMGTSTL
AAELGVSVHE AAELSDNFRR AIPGVDRWMK EVVEQCRSCG YIVTLMGRRR YFPRINERSC
KEARSQRAQS ERQAINSVCQ GSAADLVKAA MISLTRRIRE EGWAGRARLV LMVHDELVLE
VETGLLPAMA ALTRDVLEGE ERNEFIPSIP DPTNSR
//
