ID D9SKW2_CLOC7 Unreviewed; 622 AA.
AC D9SKW2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:ADL53534.1};
GN OrderedLocusNames=Clocel_3868 {ECO:0000313|EMBL:ADL53534.1};
OS Clostridium cellulovorans (strain ATCC 35296 / DSM 3052 / OCM 3 / 743B).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=573061 {ECO:0000313|EMBL:ADL53534.1, ECO:0000313|Proteomes:UP000002730};
RN [1] {ECO:0000313|EMBL:ADL53534.1, ECO:0000313|Proteomes:UP000002730}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35296 / DSM 3052 / OCM 3 / 743B
RC {ECO:0000313|Proteomes:UP000002730};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Hemme C.L., Woyke T.;
RT "Complete sequence of Clostridium cellulovorans 743B.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; CP002160; ADL53534.1; -; Genomic_DNA.
DR RefSeq; WP_010073875.1; NC_014393.1.
DR AlphaFoldDB; D9SKW2; -.
DR STRING; 573061.Clocel_3868; -.
DR MEROPS; S08.108; -.
DR KEGG; ccb:Clocel_3868; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_025670_0_0_9; -.
DR OrthoDB; 2744137at2; -.
DR Proteomes; UP000002730; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07478; Peptidases_S8_CspA-like; 1.
DR Gene3D; 2.60.120.1290; -; 1.
DR Gene3D; 3.30.70.2980; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR041365; CspB_prodomain.
DR InterPro; IPR034045; Pep_S8_CspA-like.
DR InterPro; IPR017310; Pept_S8A_subtilisin_clostridia.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF18425; CspB_prodomain; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PIRSF; PIRSF037894; Subtilisin_rel_CspABC; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002730};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 2..93
FT /note="Csp protease B prodomain"
FT /evidence="ECO:0000259|Pfam:PF18425"
FT DOMAIN 119..294
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 432..552
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 128
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 186
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 496
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 622 AA; 68547 MW; 1454FE01498694A9 CRC64;
MEKFGGKLNL LANVPEEVKM KIIEYTKSDE ILQGKLELVA LLGSDISVAR EKVQALGGVF
EDLGFGFAII TIDTNRLNEL ARISEIQYIE LPKTLFSSFV NSNNSSCINQ VWTQFEVTGK
GILVGFLDSG IDYMHQEFRE KNGDTRIDYI YDLSKGGVIY NREQINQAIK SPDPFSVVPH
IDDNGHGSHV ASIACGSGII NPRYRGVAYE SSIAMVKMTA VGKVNYGKSS QLMRGLKFLI
DKSKELSKPL SVNLSFSTND GAHDGNSLLE QYIDTICRLE RMSMAIASGN EGDAAHHASG
TITAREEINF NISGEGSQLV INLYKNILDN IAIEILNPQN VSSGVVALRP GYSQGQLMSD
RFYIYVTGPT PLSVNGEIVI SLVSEGTSLL QGQWRMIITC DNPGGRPYDI WMPVTEQLSS
ETRFLNPDPY GTLGIPATVQ RAIGVGSYNS DTNILSTFSG RGNSQEPTVK PDIVAPGENI
EAAIPGGFYD TLNGTSMAAP HVAGAAALMM EWGIIKGKDP FMYGERLKAF LVKGAKRGRP
GIIYPNTMWG YGTLCLYETF RIIQMDKRSY IESKLEARMN FSNTVSDKKT CNDDIMFFSN
TNIYFRIPPE LMGLLMNKNF FY
//
