ID D9W9B4_9ACTN Unreviewed; 942 AA.
AC D9W9B4;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Mycocerosic acid synthase {ECO:0000313|EMBL:EFL20602.1};
DE Flags: Fragment;
GN ORFNames=SSOG_00314 {ECO:0000313|EMBL:EFL20602.1};
OS Streptomyces himastatinicus ATCC 53653.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL20602.1, ECO:0000313|Proteomes:UP000003963};
RN [1] {ECO:0000313|EMBL:EFL20602.1, ECO:0000313|Proteomes:UP000003963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL20602.1,
RC ECO:0000313|Proteomes:UP000003963};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG657754; EFL20602.1; -; Genomic_DNA.
DR AlphaFoldDB; D9W9B4; -.
DR STRING; 457427.SSOG_00314; -.
DR HOGENOM; CLU_000022_16_6_11; -.
DR Proteomes; UP000003963; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 12..433
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 888..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 942
FT /evidence="ECO:0000313|EMBL:EFL20602.1"
SQ SEQUENCE 942 AA; 98613 MW; 0D976D7F100C14AC CRC64;
MRHNTPASAR PPTRIAVVGM GCRLPGDIDS PAALWHLLAE GRDAVAAPPA ERTALWGTPD
PTGPADGSGL PAVGGYLREV SGFDADFFGV SGREADVLDP QHRLLLEVAW EALEHAGTPP
DRLAGTATGV FTGLSYNDYA DRLDRYTQEQ QGSALSNAHC VAAGRISYLL GLQGPCLALD
TACSSSLVAV HLAAQALRAG ECDLALAGGV TLMFEPRVTR SFDRMGMLSH TGHCHAFDAA
ADGFVRGEGC GIVVLKRLTD AIRDRDRVLA VLRGSAVNQD GHSDGLAAPS PTAQRALYEE
ALARAGIDAR DIGMVETHGT GTPVGDPVEF SSLAEVYGTG RDRCALASVK TNLGHLEPAA
GVTGLIKAIL CLNQGLIPPN LHFTRWNPAI DAEATRFFVP RELTPWPVRT GPRLAAVSSF
GFSGTNAHVV LEQPPATPAL PRARRPRHTT TTATDPHIVL LPAGSPAALP VAARRMADWL
EGDGAAVPLR DIAHTLALRR AAGRGRLGVT ATTHGEVAQA LRAFATGRAH PAVVTGAVGA
EVSRRPVWVF SGQGSQWPGM GRGLLEREPA FAAALAEADE LIAAETGFSV LDIVRAGEPV
TGCARVQPVL FALQTALAAT WRAHGVEPAG VVGHSMGEVA AAVVAGALSL ADGVKVICRR
SALLTRVAGN GAMATVGLPA DEVQAELDTT EGRVTVAVMA APGSTVVAGD TVRVERLVAD
WEARGVPAAL VAVDVASHSP QVDPLLPELR TVLADLTPRR PDVPFYTTVL DDPHDVPAFD
AAYWCANLRR PVRFSAALAA AAADRHLVYV EISPHPVVTH PVARTLADLT RDPVVLPTLR
RGEDETTTFR TQLAALHCAG VPVDWAHLYG DGDLADVPAI TFDRTPHWAT PALPAPTADT
SARSTGELPG SHTEVPGESL RHSWRASTGT RHPALAGRPP GA
//
