ID D9W9I2_9ACTN Unreviewed; 1149 AA.
AC D9W9I2;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SSOG_00382 {ECO:0000313|EMBL:EFL20670.1};
OS Streptomyces himastatinicus ATCC 53653.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=457427 {ECO:0000313|EMBL:EFL20670.1, ECO:0000313|Proteomes:UP000003963};
RN [1] {ECO:0000313|EMBL:EFL20670.1, ECO:0000313|Proteomes:UP000003963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53653 {ECO:0000313|EMBL:EFL20670.1,
RC ECO:0000313|Proteomes:UP000003963};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "Annotation of Streptomyces hygroscopicus strain ATCC 53653.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; GG657754; EFL20670.1; -; Genomic_DNA.
DR AlphaFoldDB; D9W9I2; -.
DR STRING; 457427.SSOG_00382; -.
DR HOGENOM; CLU_000445_82_3_11; -.
DR Proteomes; UP000003963; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17574; REC_OmpR; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EFL20670.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:EFL20670.1}.
FT DOMAIN 327..542
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 642..757
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 690
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1149 AA; 123081 MW; 5640C823A290A427 CRC64;
MMSGIDWSAT SLGSTEAWPP RLVEALRIVL FTEQPMAVFW GPEYTMLYND GYADIIGSKH
PGALGRSGRA VFPENWELSV APLFETVWES RKPSLVTDRA FVIQRRGFLE QSYFDVSIQP
LLLDDGAMGG VLCVVTETTA RVLSERRLRL LAGLGARTAG LRTPQSVART VAEMLDIHRD
DVPFTAFYLV PEPGRLRLAA SAAIPPEAAE AAREVRLDRI EETTGLAARL AAVVGDAAPA
RLPGALFSMP GEEALAHPLV RSDTVEGVLV MGINPRLPAT APYQDFFEVL AATVGAALSA
ARTQHEQRRR AESLAELDRA KTVFFSNISH EFRTPLTLIL GPVQQALADE DRPARRSQLE
LAERSALRLL KLVNTLLDVS RVEAGGLKGT FEPVDLSRIT AELAAIFRSS FDLAGLTLEV
DCPPLPEPVH IDREMWEKIV LNLISNALKF TFTGGVTVRM AAVGHHARLT VSDTGSGIPR
EELPHLFERF HRVRGARSRS YEGSGVGLAL VKDLVELHSG TIAVTSVPAR GTEFTVEIPF
GTAHLEDVRG EAPSVRGGTG EAERAAAYAQ EARHWLGTAP SEPLEAEESP AGASGVAEAP
VEAPFEAPSQ APVMAPFEAP IEAPESPYAT GPAEPAPVRR PRLLVADDNA DVRSYLGDLL
GREHDVLLAA DGRAALDTAL AHPVDLVLTD VMMPRLDGFG LVRALRADPR TTRLPIIMLT
ARAGEESTVR GLGAGADDYL AKPFSARQLL ARVSANLELS RLRERVLSDS RRQADMLTSL
SQASLLLSDT LDPPQVLDTA RELLVPALAD EIRIRLADPR AERPLYAAGE SVAPGGLLDR
ALGETLLAGT APEPPATGGP LLAVPLLAHG RTLGALAIAR REGVYTMADR QYLQGVAGRL
ALAYDNAARF RNERHLALTL QRALLPQHLP QVPGLHTASY YEASASGAEI GGDWYDVIAL
PDGEMGLAIG DVMGHDVDAA TVMGRLRSTL RGFALDRASP GVLLGKLDAY LRSLDVDHFA
TCLYAVYEPR TRRLRYAASG HLPPLLVAGG TTSFLDVCPN APLGLADEPP VGHETRLPPG
AGLLLFTDGL VENSHLPLDD GLAALRRACD GLTPPVLADP QAIIDRALGL LDIPGRVDDD
TALLAASAP
//
